3FQW
Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted antigen presentation and generates tumor specific epitopes
Summary for 3FQW
Entry DOI | 10.2210/pdb3fqw/pdb |
Related | 3FQN 3FQR 3FQT 3FQU 3FQX |
Descriptor | HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, peptide 1097-1105 from insulin receptor substrate 2 (IRS2): RVASPTSGV, ... (6 entities in total) |
Functional Keywords | immune system, phosphorylation, glycoprotein, immune response, membrane, mhc i, phosphoprotein, polymorphism, transmembrane, ubl conjugation, disease mutation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, cancer, tcr, self-epitope |
Biological source | Homo sapiens (Human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted . Note=(Microbial infection) In the presence of M: P61769 |
Total number of polymer chains | 3 |
Total formula weight | 44984.17 |
Authors | Petersen, J.,Rossjohn, J. (deposition date: 2009-01-07, release date: 2009-03-03, Last modification date: 2023-11-01) |
Primary citation | Petersen, J.,Wurzbacher, S.J.,Williamson, N.A.,Ramarathinam, S.H.,Reid, H.H.,Nair, A.K.,Zhao, A.Y.,Nastovska, R.,Rudge, G.,Rossjohn, J.,Purcell, A.W. Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes Proc.Natl.Acad.Sci.Usa, 106:2776-2781, 2009 Cited by PubMed: 19196958DOI: 10.1073/pnas.0812901106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.927 Å) |
Structure validation
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