PDB: 46984 件ウェブページステータス検索Chemie searchBIRD

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4G99	Rat Heme Oxygenase-1 in complex with Heme and CO at 100 K after warming to 160 K 分子名称: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-23 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
4X7W	MycF mycinamicin III 3'-O-methyltransferase (E35Q, E139A variant) in complex with Mg, SAH and mycinamicin VI (MycE substrate) 分子名称: MAGNESIUM ION, Mycinamicin III 3''-O-methyltransferase, Mycinamicin VI, ... 著者 Bernard, S.M, Smith, J.L. 登録日 2014-12-09 公開日 2015-03-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases. Acs Chem.Biol., 10, 2015
4ISL	Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1 分子名称: GLUTATHIONE, GLYCEROL, Kunitz-type protease inhibitor 1, ... 著者 Huang, M.D, Zhao, B.Y, Yuan, C, Li, R. 登録日 2013-01-16 公開日 2013-03-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1. J.Biol.Chem., 288, 2013
4WO1	Crystal structure of the DAP12 transmembrane domain in lipid cubic phase 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, TYRO protein tyrosine kinase-binding protein 著者 Call, M.J, Call, M.E, Knoblich, K. 登録日 2014-10-15 公開日 2015-06-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly. Cell Rep, 11, 2015
4G8W	Rat Heme Oxygenase-1 in complex with Heme and O2 with 13 hr illumination: Laser on 分子名称: FORMIC ACID, Heme oxygenase 1, OXYGEN MOLECULE, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-23 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
4GJZ	JMJD5 in complex with 2-oxoglutarate 分子名称: 2-OXOGLUTARIC ACID, BETA-MERCAPTOETHANOL, COBALT (II) ION, ... 著者 Del Rizzo, P.A, Trievel, R.C. 登録日 2012-08-10 公開日 2012-09-05 最終更新日 2012-11-14 実験手法 X-RAY DIFFRACTION (1.0481 Å) 主引用文献 Crystal Structure and Functional Analysis of JMJD5 Indicate an Alternate Specificity and Function. Mol.Cell.Biol., 32, 2012
4JLT	Crystal structure of P450 2B4(H226Y) in complex with paroxetine 分子名称: 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, Cytochrome P450 2B4, GLYCEROL, ... 著者 Shah, M.B, Pascual, J, Stout, C.D, Halpert, J.R. 登録日 2013-03-13 公開日 2013-06-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 A Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational States. J.Pharmacol.Exp.Ther., 346, 2013
5W0S	GroEL using cryoEM 分子名称: 60 kDa chaperonin 著者 Roh, S.H, Chiu, W. 登録日 2017-05-31 公開日 2017-08-09 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Subunit conformational variation within individual GroEL oligomers resolved by Cryo-EM. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4G7T	Rat Heme Oxygenase-1 in complex with Heme and CO with 1 hr Illumination: Laser on 分子名称: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-20 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
4G98	Rat Heme Oxygenase-1 in complex with Heme and CO at 100K 分子名称: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-23 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
4G8U	Rat Heme Oxygenase-1 in complex with Heme and O2 with 13 hr illumination: Laser off 分子名称: FORMIC ACID, Heme oxygenase 1, OXYGEN MOLECULE, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-23 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
4X7I	Crystal Structure of BACE with amino thiazine inhibitor LY2886721 分子名称: Beta-secretase 1, GLYCEROL, N-{3-[(4aS,7aS)-2-amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide 著者 Timm, D.E. 登録日 2014-12-09 公開日 2014-12-24 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central A beta Pharmacodynamic Responses in Mice, Dogs, and Humans. J.Neurosci., 35, 2015
5W18	Staphylococcus aureus ClpP in complex with (S)-N-((2R,6S,8aS,14aS,20S,23aS)-2,6-dimethyl-5,8,14,19,23-pentaoxooctadecahydro-1H,5H,14H,19H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-20-yl)-3-phenyl-2-(3-phenylureido)propanamide 分子名称: 9V7-PHE-SER-PRO-YCP-ALA-MP8, ATP-dependent Clp protease proteolytic subunit 著者 Lee, R.E, Griffith, E.C. 登録日 2017-06-02 公開日 2017-08-09 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Ureadepsipeptides as ClpP Activators. Acs Infect Dis., 2019
4G7P	Rat Heme Oxygenase-1 in complex with Heme and CO with 1 hr Illumination at 100 K: Laser off 分子名称: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-20 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
4G8P	Rat Heme Oxygenase-1 in complex with Heme and CO with 16 hr Illumination: Laser on 分子名称: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-23 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
4DUE	cytochrome P450 BM3h-2G9C6 MRI sensor bound to serotonin 分子名称: PROTOPORPHYRIN IX CONTAINING FE, SEROTONIN, cytochrome P450 BM3 variant 2G9C6 著者 Brustad, E.M, Lelyveld, V.S, Snow, C.D, Crook, N, Martinez, F.M, Scholl, T.J, Jasanoff, A, Arnold, F.H. 登録日 2012-02-21 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-guided directed evolution of highly selective p450-based magnetic resonance imaging sensors for dopamine and serotonin. J.Mol.Biol., 422, 2012
5UOJ	THE STRUCTURE OF THE MAP KINASE P38 AT 2.1 ANGSTROMS RESOLUTION 分子名称: Mitogen-activated protein kinase 14 著者 CHLEBOWICZ, J, WANG, Z, GOLDSMITH, E.J. 登録日 2017-01-31 公開日 2017-02-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc. Natl. Acad. Sci. U.S.A., 94, 1997
5VG1	Neutron crystallographic structure of a Jonesia denitrificans lytic polysaccharide monooxygenase 分子名称: COPPER (II) ION, Chitinase, PEROXIDE ION 著者 Bacik, J.-P, Unkefer, C.J, Chen, J.C.H. 登録日 2017-04-10 公開日 2017-05-24 最終更新日 2023-10-04 実験手法 NEUTRON DIFFRACTION (2.1 Å) 主引用文献 Neutron and Atomic Resolution X-ray Structures of a Lytic Polysaccharide Monooxygenase Reveal Copper-Mediated Dioxygen Binding and Evidence for N-Terminal Deprotonation. Biochemistry, 56, 2017
5VGI	Crystal Structure of KDM4 with the Small Molecule Inhibitor QC6352 分子名称: 3-[({(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl}methyl)amino]pyridine-4-carboxylic acid, Lysine-specific demethylase 4A, NICKEL (II) ION, ... 著者 Hosfield, D.J. 登録日 2017-04-11 公開日 2017-09-27 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models. ACS Med Chem Lett, 8, 2017
7Q21	III2-IV2 respiratory supercomplex from Corynebacterium glutamicum 分子名称: (1R)-2-(dodecanoyloxy)-1-[(phosphonooxy)methyl]ethyl tetradecanoate, (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ... 著者 Kovalova, T, Moe, A, Krol, S, Yanofsky, D.J, Bott, M, Sjostrand, D, Rubinstein, J.L, Hogbom, M, Brzezinski, P. 登録日 2021-10-22 公開日 2022-02-02 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 The respiratory supercomplex from C. glutamicum. Structure, 30, 2022
5WJJ	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors 分子名称: Mitogen-activated protein kinase 14, N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methyl-1-oxo-1lambda~5~-pyridine-4-carboxamide 著者 Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. 登録日 2017-07-23 公開日 2018-01-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors. Bioorg. Med. Chem., 26, 2018
4FGX	Crystal structure of bace1 with novel inhibitor 分子名称: Beta-secretase 1, DI(HYDROXYETHYL)ETHER, Inhibitor (2R,5S,8S,12S,13S,16S,19S,22S)-16-(3-amino-3-oxopropyl)-2,13-dibenzyl-12,22-dihydroxy-8-isobutyl-19-isopropyl-3,5,17-trimethyl-4,7,10,15,18,21-hexaoxo-3,6,9,14,17,20-hexaazatricosan-1-oic acid, ... 著者 Chen, T.T, Chen, W.Y, Li, L, Xu, Y.C. 登録日 2012-06-05 公開日 2013-01-16 最終更新日 2021-09-15 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases J.Med.Chem., 55, 2012
4KCP	Structure of bovine endotheial nitric oxide synthase heme domain in complex with N-(4-(2-((3-(thiophene-2-carboximidamido)benzyl)amino)ethyl)phenyl)thiophene-2-carboximidamide 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, GLYCEROL, ... 著者 Chreifi, G, Li, H, Poulos, T.L. 登録日 2013-04-24 公開日 2014-02-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma. J.Med.Chem., 57, 2014
4H23	Cytochrome P411BM3-CIS cyclopropanation catalyst 分子名称: Cytochrome P450-BM3 variant P411BM3-Cis, PROTOPORPHYRIN IX CONTAINING FE 著者 Coelho, P.S, Wang, Z.J, Ener, M.E, Baril, S.A, Kannan, A, Arnold, F.H, Brustad, E.M. 登録日 2012-09-11 公開日 2013-06-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo. Nat.Chem.Biol., 9, 2013
4JYT	Crystal Structure of Matriptase in complex with Inhibitor 分子名称: 4,4'-[{3-[(naphthalen-2-ylsulfonyl)amino]pyridine-2,6-diyl}bis(oxy)]dibenzenecarboximidamide, Suppressor of tumorigenicity 14 protein 著者 Subramanya, H.S, Ravi, B.C, Ashok, K.N, Chakshusmathi, G, Ramesh, K.S. 登録日 2013-04-01 公開日 2014-03-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors ACS MED.CHEM.LETT., 4, 2013

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