4X7W
MycF mycinamicin III 3'-O-methyltransferase (E35Q, E139A variant) in complex with Mg, SAH and mycinamicin VI (MycE substrate)
Summary for 4X7W
Entry DOI | 10.2210/pdb4x7w/pdb |
Related | 4X7U 4X7V 4X7X 4X7Y 4X7Z 4X81 |
Descriptor | Mycinamicin III 3''-O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | macrolide, methyltransferase, antibiotic, natural product, transferase-antiobiotic complex, transferase/antiobiotic |
Biological source | Micromonospora griseorubida |
Total number of polymer chains | 2 |
Total formula weight | 63668.17 |
Authors | Bernard, S.M.,Smith, J.L. (deposition date: 2014-12-09, release date: 2015-03-04, Last modification date: 2023-09-27) |
Primary citation | Bernard, S.M.,Akey, D.L.,Tripathi, A.,Park, S.R.,Konwerski, J.R.,Anzai, Y.,Li, S.,Kato, F.,Sherman, D.H.,Smith, J.L. Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases. Acs Chem.Biol., 10:1340-1351, 2015 Cited by PubMed: 25692963DOI: 10.1021/cb5009348 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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