5W18

Staphylococcus aureus ClpP in complex with (S)-N-((2R,6S,8aS,14aS,20S,23aS)-2,6-dimethyl-5,8,14,19,23-pentaoxooctadecahydro-1H,5H,14H,19H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-20-yl)-3-phenyl-2-(3-phenylureido)propanamide

Summary for 5W18

• Entry DOI: 10.2210/pdb5w18/pdb
• Descriptor: ATP-dependent Clp protease proteolytic subunit, 9V7-PHE-SER-PRO-YCP-ALA-MP8 (3 entities in total)
• Functional Keywords: clpp, hydrolase-antibiotic complex, udep, hydrolase/antibiotic
• Biological source: Staphylococcus aureus (strain NCTC 8325); More
• Total number of polymer chains: 28
• Total formula weight: 327173.70

Authors

Lee, R.E.,Griffith, E.C. (deposition date: 2017-06-02, release date: 2017-08-09, Last modification date: 2023-11-15)

• Primary citation: Griffith, E.C.,Zhao, Y.,Singh, A.P.,Conlon, B.P.,Tangallapally, R.,Shadrick, W.R.,Liu, J.,Wallace, M.J.,Yang, L.,Elmore, J.M.,Li, Y.,Zheng, Z.,Miller, D.J.,Cheramie, M.N.,Lee, R.B.,LaFleur, M.D.,Lewis, K.,Lee, R.E.; Ureadepsipeptides as ClpP Activators.; Acs Infect Dis., 2019; PubMed: 31588734; DOI: 10.1021/acsinfecdis.9b00245

Experimental method

X-RAY DIFFRACTION (2.44 Å)