4JLT
Crystal structure of P450 2B4(H226Y) in complex with paroxetine
Summary for 4JLT
Entry DOI | 10.2210/pdb4jlt/pdb |
Related | 1PO5 1SUO 2BDM 2Q6N 3G5N 3G93 3KW4 3ME6 3MVR 3R1A 3R1B 3TK3 3TMZ 3UAS 4H1N |
Descriptor | Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ... (8 entities in total) |
Functional Keywords | p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, me protein, cyp 2b4 |
Biological source | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P00178 |
Total number of polymer chains | 1 |
Total formula weight | 57264.94 |
Authors | Shah, M.B.,Pascual, J.,Stout, C.D.,Halpert, J.R. (deposition date: 2013-03-13, release date: 2013-06-26, Last modification date: 2023-09-20) |
Primary citation | Shah, M.B.,Kufareva, I.,Pascual, J.,Zhang, Q.,Stout, C.D.,Halpert, J.R. A Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational States. J.Pharmacol.Exp.Ther., 346:113-120, 2013 Cited by PubMed: 23633618DOI: 10.1124/jpet.113.204776 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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