4JLT

Crystal structure of P450 2B4(H226Y) in complex with paroxetine

Summary for 4JLT

Entry DOI	10.2210/pdb4jlt/pdb
Related	1PO5 1SUO 2BDM 2Q6N 3G5N 3G93 3KW4 3ME6 3MVR 3R1A 3R1B 3TK3 3TMZ 3UAS 4H1N
Descriptor	Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ... (8 entities in total)
Functional Keywords	p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, me protein, cyp 2b4
Biological source	Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
Total number of polymer chains	1
Total formula weight	57264.94
Authors	Shah, M.B.,Pascual, J.,Stout, C.D.,Halpert, J.R. (deposition date: 2013-03-13, release date: 2013-06-26, Last modification date: 2023-09-20)
Primary citation	Shah, M.B.,Kufareva, I.,Pascual, J.,Zhang, Q.,Stout, C.D.,Halpert, J.R. A Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational States. J.Pharmacol.Exp.Ther., 346:113-120, 2013 Cited by PubMed: 23633618 DOI: 10.1124/jpet.113.204776 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation