3KW4
Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug ticlopidine
Summary for 3KW4
Entry DOI | 10.2210/pdb3kw4/pdb |
Related | 1PO5 1SUO 2BDM 2Q6N 3G5N 3G93 |
Descriptor | Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, ticlopidine, ... (6 entities in total) |
Functional Keywords | p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4, cyp lm2, endoplasmic reticulum, heme, iron, membrane, metal-binding, microsome |
Biological source | Oryctolagus cuniculus (rabbit) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P00178 |
Total number of polymer chains | 1 |
Total formula weight | 57522.09 |
Authors | Gay, S.C.,Maekawa, K.,Roberts, A.G.,Hong, W.-X.,Zhang, Q.,Stout, C.D.,Halpert, J.R. (deposition date: 2009-11-30, release date: 2010-09-15, Last modification date: 2023-09-06) |
Primary citation | Gay, S.C.,Roberts, A.G.,Maekawa, K.,Talakad, J.C.,Hong, W.X.,Zhang, Q.,Stout, C.D.,Halpert, J.R. Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel. Biochemistry, 49:8709-8720, 2010 Cited by PubMed: 20815363DOI: 10.1021/bi100914z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.67 Å) |
Structure validation
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