1Y67
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1LVY
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![BU of 1lvy by Molmil](/molmil-images/mine/1lvy) | PORCINE ELASTASE | 分子名称: | CALCIUM ION, ELASTASE, SULFATE ION | 著者 | Schiltz, M, Prange, T. | 登録日 | 1996-07-20 | 公開日 | 1997-01-27 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | High-pressure krypton gas and statistical heavy-atom refinement: a successful combination of tools for macromolecular structure determination. Acta Crystallogr.,Sect.D, 53, 1997
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4UHV
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![BU of 4uhv by Molmil](/molmil-images/mine/4uhv) | The structure of VgrG1, the needle tip of the bacterial Type VI Secretion System | 分子名称: | CHLORIDE ION, SODIUM ION, VGRG1, ... | 著者 | Spinola-Amilibia, M, Davo-Siguero, I, Ruiz, F.M, Santillana, E, Medrano, F.J, Romero, A. | 登録日 | 2015-03-25 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Structure of Vgrg1 from Pseudomonas Aeruginosa, the Needle Tip of the Bacterial Type Vi Secretion System Acta Crystallogr.,Sect.D, 72, 2016
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6JT4
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![BU of 6jt4 by Molmil](/molmil-images/mine/6jt4) | Crystal Structure of BACE1 in complex with N-{3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide | 分子名称: | Beta-secretase 1, GLYCEROL, IODIDE ION, ... | 著者 | Anan, K, Iso, Y, Oguma, T, Nakahara, K, Suzuki, S, Yamamoto, T, Matsuoka, E, Ito, H, Sakaguchi, G, Ando, S, Morimoto, K, Kanegawa, N, Kido, Y, Kawachi, T, Fukushima, T, Teisman, A, Urmaliya, V, Dhuyvetter, D, Borghys, H, Austin, N, Bergh, A.V.D, Verboven, P, Bischoff, F, Gijsen, H.J.M, Yamano, Y, Kusakabe, K.I. | 登録日 | 2019-04-08 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Trifluoromethyl Dihydrothiazine-Based beta-Secretase (BACE1) Inhibitors with Robust Central beta-Amyloid Reduction and Minimal Covalent Binding Burden. Chemmedchem, 14, 2019
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1EB6
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![BU of 1eb6 by Molmil](/molmil-images/mine/1eb6) | Deuterolysin from Aspergillus oryzae | 分子名称: | 1,2-ETHANEDIOL, NEUTRAL PROTEASE II, ZINC ION | 著者 | McAuley, K.E, Jia-Xing, Y, Dodson, E.J, Lehmbeck, J, Ostergaard, P.R, Wilson, K.S. | 登録日 | 2001-07-19 | 公開日 | 2001-11-23 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | A Quick Solution: Ab Initio Structure Determination of a 19 kDa Metalloproteinase Using Acorn Acta Crystallogr.,Sect.D, 57, 2001
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1FHJ
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7T4J
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![BU of 7t4j by Molmil](/molmil-images/mine/7t4j) | Crystal Structure of EGFR_D770_N771insNPG/V948R in complex with TAK-788 | 分子名称: | 1,2-ETHANEDIOL, CITRIC ACID, Epidermal growth factor receptor, ... | 著者 | Skene, R.J, Lane, W, Hu, Y. | 登録日 | 2021-12-10 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer. Bioorg.Med.Chem.Lett., 80, 2022
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7T4I
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![BU of 7t4i by Molmil](/molmil-images/mine/7t4i) | Crystal Structure of wild type EGFR in complex with TAK-788 | 分子名称: | Epidermal growth factor receptor, propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | 著者 | Skene, R.J, Lane, W. | 登録日 | 2021-12-10 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer. Bioorg.Med.Chem.Lett., 80, 2022
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7OKB
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![BU of 7okb by Molmil](/molmil-images/mine/7okb) | Crystal structure of Pseudomonas aeruginosa LpxA in complex with compound 45 | 分子名称: | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, CHLORIDE ION, SULFATE ION, ... | 著者 | Ryan, M.D, Parkes, A.L, Southey, M, Andersen, O.A, Zahn, M, Barker, J, DeJonge, B.L.M. | 登録日 | 2021-05-17 | 公開日 | 2021-10-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.58 Å) | 主引用文献 | Discovery of Novel UDP- N -Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa . J.Med.Chem., 64, 2021
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7OKC
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![BU of 7okc by Molmil](/molmil-images/mine/7okc) | Crystal structure of Escherichia coli LpxA in complex with compound 1 | 分子名称: | 2-[2-(2-chlorophenyl)sulfanylethanoyl-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]amino]-N-methyl-ethanamide, Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, SODIUM ION | 著者 | Ryan, M.D, Parkes, A.L, Southey, M, Andersen, O.A, Zahn, M, Barker, J, DeJonge, B.L.M. | 登録日 | 2021-05-17 | 公開日 | 2021-10-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Discovery of Novel UDP- N -Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa . J.Med.Chem., 64, 2021
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7OKA
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![BU of 7oka by Molmil](/molmil-images/mine/7oka) | Crystal structure of Pseudomonas aeruginosa LpxA in complex with compound 14 | 分子名称: | 2-(2-chlorophenyl)sulfanyl-~{N}-[(4-cyanophenyl)methyl]-~{N}-(1~{H}-imidazol-4-ylmethyl)ethanamide, Acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase, CHLORIDE ION, ... | 著者 | Ryan, M.D, Parkes, A.L, Southey, M, Andersen, O.A, Zahn, M, Barker, J, DeJonge, B.L.M. | 登録日 | 2021-05-17 | 公開日 | 2021-10-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Discovery of Novel UDP- N -Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa . J.Med.Chem., 64, 2021
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7OWY
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![BU of 7owy by Molmil](/molmil-images/mine/7owy) | Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 3 minutes showing a peroxide anion as bridging species of iron ions in the ferroxidase site | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | 著者 | Pozzi, C, Ciambellotti, S, Tassone, G, Turano, P, Mangani, S. | 登録日 | 2021-06-21 | 公開日 | 2021-10-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin. Chemistry, 27, 2021
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5TR0
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![BU of 5tr0 by Molmil](/molmil-images/mine/5tr0) | Lipoxygenase-1 (soybean) L754A mutant at 293K | 分子名称: | FE (II) ION, Seed linoleate 13S-lipoxygenase-1 | 著者 | Poss, E.M, Fraser, J.S. | 登録日 | 2016-10-24 | 公開日 | 2017-11-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network. J.Am.Chem.Soc., 141, 2019
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5TQP
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![BU of 5tqp by Molmil](/molmil-images/mine/5tqp) | LIPOXYGENASE-1 (SOYBEAN) I553G MUTANT AT 300K | 分子名称: | FE (III) ION, Seed linoleate 13S-lipoxygenase-1 | 著者 | Poss, E.M, Fraser, J.S. | 登録日 | 2016-10-24 | 公開日 | 2017-11-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling. ACS Cent Sci, 3, 2017
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5TQO
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![BU of 5tqo by Molmil](/molmil-images/mine/5tqo) | Lipoxygenase-1 (soybean) L546A/L754A mutant at 300K | 分子名称: | FE (III) ION, Seed linoleate 13S-lipoxygenase-1 | 著者 | Poss, E.M, Fraser, J.S, Gee, C. | 登録日 | 2016-10-24 | 公開日 | 2017-11-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network. J.Am.Chem.Soc., 141, 2019
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5TQN
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![BU of 5tqn by Molmil](/molmil-images/mine/5tqn) | Lipoxygenase-1 (soybean) L546A mutant at 293K | 分子名称: | FE (II) ION, Seed linoleate 13S-lipoxygenase-1 | 著者 | Poss, E.M, Fraser, J.S, Gee, C. | 登録日 | 2016-10-24 | 公開日 | 2017-11-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network. J.Am.Chem.Soc., 141, 2019
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5T5V
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![BU of 5t5v by Molmil](/molmil-images/mine/5t5v) | LIPOXYGENASE-1 (SOYBEAN) AT 293K | 分子名称: | FE (III) ION, Seed linoleate 13S-lipoxygenase-1 | 著者 | Poss, E.M, Fraser, J.S. | 登録日 | 2016-08-31 | 公開日 | 2017-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling. ACS Cent Sci, 3, 2017
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5T9F
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![BU of 5t9f by Molmil](/molmil-images/mine/5t9f) | Prephenate Dehydrogenase N222D mutant from Soybean | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Prephenate dehydrogenase 1, TYROSINE | 著者 | Holland, C.K, Jez, J.M. | 登録日 | 2016-09-09 | 公開日 | 2017-06-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.994 Å) | 主引用文献 | Molecular basis of the evolution of alternative tyrosine biosynthetic routes in plants. Nat. Chem. Biol., 13, 2017
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4Y9A
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5AFS
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![BU of 5afs by Molmil](/molmil-images/mine/5afs) | structure of Zn-bound periplasmic metal binding protein from candidatus liberibacter asiaticus | 分子名称: | ACETATE ION, GLYCEROL, PERIPLASMIC SOLUTE BINDING PROTEIN, ... | 著者 | Sharma, N, Selvakumar, P, Kumar, P, Sharma, A.K. | 登録日 | 2015-01-23 | 公開日 | 2016-02-24 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Crystal structure analysis in Zn(2+)-bound state and biophysical characterization of CLas-ZnuA2. Biochim. Biophys. Acta, 1864, 2016
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4Y8F
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4Y96
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![BU of 4y96 by Molmil](/molmil-images/mine/4y96) | Crystal structure of Triosephosphate Isomerase from Gemmata obscuriglobus | 分子名称: | CALCIUM ION, PHOSPHATE ION, SODIUM ION, ... | 著者 | Romero-Romero, S, Rodriguez-Romero, A, Fernandez-Velasco, D.A. | 登録日 | 2015-02-17 | 公開日 | 2015-07-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.581 Å) | 主引用文献 | Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins. Phys Chem Chem Phys, 17, 2015
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4Y90
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![BU of 4y90 by Molmil](/molmil-images/mine/4y90) | Crystal structure of Triosephosphate Isomerase from Deinococcus radiodurans | 分子名称: | CALCIUM ION, GLYCEROL, SODIUM ION, ... | 著者 | Romero-Romero, S, Rodriguez-Romero, A, Fernadez-Velasco, D.A. | 登録日 | 2015-02-16 | 公開日 | 2015-07-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins. Phys Chem Chem Phys, 17, 2015
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4ABI
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![BU of 4abi by Molmil](/molmil-images/mine/4abi) | Co-complex structure of bovine trypsin with a modified Bowman-Birk inhibitor (PtA)SFTI-1(1,14), that was 1,4-disubstituted with a 1,2,3- trizol to mimic a trans amide bond | 分子名称: | CALCIUM ION, CATIONIC TRYPSIN, DIMETHYLFORMAMIDE, ... | 著者 | Schmelz, S, Empting, M, Tischler, M, Nasu, D, Heinz, D, Kolmar, H. | 登録日 | 2011-12-08 | 公開日 | 2012-03-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Braces for the Peptide Backbone: Insights Into Structure-Activity Relation-Ships of Protease Inhibitor Mimics with Locked Amide Conformations Angew.Chem.Int.Ed.Engl., 51, 2012
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5T95
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