4V25
VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context- dependent cytostasis in cancer cells
Summary for 4V25
Entry DOI | 10.2210/pdb4v25/pdb |
Related | 4V26 |
Descriptor | [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 2, MITOCHONDRIAL, N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | transferase, glycolysis, warburg metabolism, nov3r |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 47228.87 |
Authors | Moore, J.D.,Staniszewska, A.,Shaw, T.,D'Alessandro, J.,Davis, B.,Surgenor, A.,Baker, L.,Matassova, N.,Murray, J.,Macias, A.,Brough, P.,Wood, M.,Mahon, P.C. (deposition date: 2014-10-06, release date: 2014-12-03, Last modification date: 2024-05-01) |
Primary citation | Moore, J.D.,Staniszewska, A.,Shaw, T.,D'Alessandro, J.,Davis, B.,Surgenor, A.,Baker, L.,Matassova, N.,Murray, J.,Macias, A.,Brough, P.,Wood, M.,Mahon, P.C. VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Oncotarget, 5:12862-12876, 2014 Cited by PubMed: 25404640DOI: 10.18632/oncotarget.2656 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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