4F21

Crystal structure of carboxylesterase/phospholipase family protein from Francisella tularensis

Summary for 4F21

• Entry DOI: 10.2210/pdb4f21/pdb
• Descriptor: Carboxylesterase/phospholipase family protein, N-((1R,2S)-2-allyl-4-oxocyclobutyl)-4-methylbenzenesulfonamide, bound form (3 entities in total)
• Functional Keywords: structural genomics, niaid, national institute of allergy and infectious diseases, center for structural genomics of infectious diseases, csgid, carboxylesterase, phospholipase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Francisella tularensis subsp. tularensis
• Total number of polymer chains: 8
• Total formula weight: 219795.92

Authors

Filippova, E.V.,Minasov, G.,Kuhn, M.,Wawrzak, Z.,Shuvalova, L.,Dubrovska, I.,Winsor, J.R.,Kiryukhina, O.,Becker, D.P.,Armoush, N.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2012-05-07, release date: 2012-08-29, Last modification date: 2023-09-13)

• Primary citation: Filippova, E.V.,Weston, L.A.,Kuhn, M.L.,Geissler, B.,Gehring, A.M.,Armoush, N.,Adkins, C.T.,Minasov, G.,Dubrovska, I.,Shuvalova, L.,Winsor, J.R.,Lavis, L.D.,Satchell, K.J.,Becker, D.P.,Anderson, W.F.,Johnson, R.J.; Large scale structural rearrangement of a serine hydrolase from Francisella tularensis facilitates catalysis.; J.Biol.Chem., 288:10522-10535, 2013; PubMed: 23430251; DOI: 10.1074/jbc.M112.446625

Experimental method

X-RAY DIFFRACTION (2.5 Å)