3G4K

Crystal structure of human phosphodiesterase 4d with rolipram

Summary for 3G4K

Entry DOI	10.2210/pdb3g4k/pdb
Related	3G45 3G4G 3G4I 3G4L 3G58 3GPZ
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (7 entities in total)
Functional Keywords	phosphodiesterase, pde4d, alternative splicing, camp, cytoplasm, cytoskeleton, hydrolase, membrane, metal-binding, phosphoprotein
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q08499
Total number of polymer chains	4
Total formula weight	177778.04
Authors	Staker, B.L. (deposition date: 2009-02-03, release date: 2010-01-19, Last modification date: 2024-02-21)
Primary citation	Burgin, A.B.,Magnusson, O.T.,Singh, J.,Witte, P.,Staker, B.L.,Bjornsson, J.M.,Thorsteinsdottir, M.,Hrafnsdottir, S.,Hagen, T.,Kiselyov, A.S.,Stewart, L.J.,Gurney, M.E. Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28:63-70, 2010 Cited by PubMed: 20037581 DOI: 10.1038/nbt.1598 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation