8J25
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![BU of 8j25 by Molmil](/molmil-images/mine/8j25) | Crystal structure of PML B-box2 mutant | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Protein PML, ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Zhou, C, Zang, N, Zhang, J. | 登録日 | 2023-04-14 | 公開日 | 2023-09-20 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function. Cancer Discov, 13, 2023
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6D4F
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![BU of 6d4f by Molmil](/molmil-images/mine/6d4f) | Crystal structure of PTP epsilon D2 domain (A455N/V457Y/E597D) | 分子名称: | PENTAETHYLENE GLYCOL, Receptor-type tyrosine-protein phosphatase epsilon | 著者 | Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S. | 登録日 | 2018-04-18 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.909 Å) | 主引用文献 | High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design. Acta Crystallogr D Struct Biol, 74, 2018
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6D4D
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![BU of 6d4d by Molmil](/molmil-images/mine/6d4d) | Crystal structure of the PTP epsilon D1 domain | 分子名称: | Receptor-type tyrosine-protein phosphatase epsilon | 著者 | Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S. | 登録日 | 2018-04-18 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.765 Å) | 主引用文献 | High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design. Acta Crystallogr D Struct Biol, 74, 2018
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4E0V
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![BU of 4e0v by Molmil](/molmil-images/mine/4e0v) | Structure of L-amino acid oxidase from the B. jararacussu venom | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, L-amino-acid oxidase | 著者 | Ullah, A, Souza, T.A.C.B, Betzel, C, Murakami, M.T, Arni, R.K. | 登録日 | 2012-03-05 | 公開日 | 2012-04-25 | 最終更新日 | 2012-08-15 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural insights into selectivity and cofactor binding in snake venom L-amino acid oxidases. Biochem.Biophys.Res.Commun., 421, 2012
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3I3H
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![BU of 3i3h by Molmil](/molmil-images/mine/3i3h) | |
5AIK
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![BU of 5aik by Molmil](/molmil-images/mine/5aik) | Human DYRK1A in complex with LDN-211898 | 分子名称: | 4-(7-METHOXY-1-(TRIFLUOROMETHYL)-9H-PYRIDO[3,4-B]INDOL-9-yl)butan-1-amine, DYRK1A DUAL-SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASE 1A, PHOSPHATE ION | 著者 | Elkins, J.M, Soundararajan, M, Muniz, J.R.C, Cuny, G, Higgins, J, Edwards, A, Bountra, C, Knapp, S. | 登録日 | 2015-02-15 | 公開日 | 2015-02-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Dyrk1A with Ldn-211898 To be published
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4AZF
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![BU of 4azf by Molmil](/molmil-images/mine/4azf) | Human DYRK2 in complex with Leucettine L41 | 分子名称: | 1,2-ETHANEDIOL, 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one, DYRK2 DUAL-SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASE 2, ... | 著者 | Elkins, J.M, Soundararajan, M, Muniz, J.R.C, Tahtouh, T, Burgy, G, Durieu, E, Lozach, O, Cochet, C, Schmid, R.S, Lo, D.C, Delhommel, F, Carreaux, F, Bazureau, J.P, Meijer, L, Edwards, A, Bountra, C, Knapp, S. | 登録日 | 2012-06-25 | 公開日 | 2012-09-05 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Selectivity, Co-Crystal Structures and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B. J.Med.Chem., 55, 2012
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4AZE
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![BU of 4aze by Molmil](/molmil-images/mine/4aze) | Human DYRK1A in complex with Leucettine L41 | 分子名称: | 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one, DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A | 著者 | Elkins, J.M, Soundararajan, M, Muniz, J.R.C, Tahtouh, T, Burgy, G, Durieu, E, Lozach, O, Cochet, C, Schmid, R.S, Lo, D.C, Delhommel, F, Carreaux, F, Bazureau, J.P, Meijer, L, Edwards, A, Bountra, C, Knapp, S. | 登録日 | 2012-06-25 | 公開日 | 2012-09-05 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Selectivity, Co-Crystal Structures and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B. J.Med.Chem., 55, 2012
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6D3F
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![BU of 6d3f by Molmil](/molmil-images/mine/6d3f) | Crystal Structure of the PTP epsilon D2 domain | 分子名称: | Receptor-type tyrosine-protein phosphatase epsilon | 著者 | Lountos, G.T, Raran-Kurussi, S, Zhao, B.M, Dyas, B.K, Austin, B.P, Burke Jr, T.R, Ulrich, R.G, Waugh, D.S. | 登録日 | 2018-04-16 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.271 Å) | 主引用文献 | High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design. Acta Crystallogr D Struct Biol, 74, 2018
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1UMV
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![BU of 1umv by Molmil](/molmil-images/mine/1umv) | Crystal structure of an acidic, non-myotoxic phospholipase A2 from the venom of Bothrops jararacussu | 分子名称: | CALCIUM ION, HYPOTENSIVE PHOSPHOLIPASE A2 | 著者 | Murakami, M.T, Watanabe, L, Cintra, A.C.O, Arni, R.K. | 登録日 | 2003-08-28 | 公開日 | 2003-09-18 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Crystal Structure of an Acidic Platelet Aggregation Inhibitor and Hypotensive Phospholipase A(2) in the Monomeric and Dimeric States: Insights Into its Oligomeric State Biochem.Biophys.Res.Commun., 323, 2004
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1NCV
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![BU of 1ncv by Molmil](/molmil-images/mine/1ncv) | DETERMINATION CC-CHEMOKINE MCP-3, NMR, 7 STRUCTURES | 分子名称: | MONOCYTE CHEMOATTRACTANT PROTEIN 3 | 著者 | Meunier, S, Bernassau, J.M, Guillemot, J.C, Ferrara, P, Darbon, H. | 登録日 | 1997-02-05 | 公開日 | 1997-10-15 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy. Biochemistry, 36, 1997
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5YIO
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![BU of 5yio by Molmil](/molmil-images/mine/5yio) | NMR solution structure of subunit epsilon of the Mycobacterium tuberculosis F-ATP synthase | 分子名称: | ATP synthase epsilon chain | 著者 | Shin, J, Ragunathan, P, Sundararaman, L, Nartey, W, Manimekalai, M.S.S, Bogdanovic, N, Gruber, G. | 登録日 | 2017-10-06 | 公開日 | 2018-10-10 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | The NMR solution structure of Mycobacterium tuberculosis F-ATP synthase subunit epsilon provides new insight into energy coupling inside the rotary engine. FEBS J., 285, 2018
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3CEK
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![BU of 3cek by Molmil](/molmil-images/mine/3cek) | Crystal structure of human dual specificity protein kinase (TTK) | 分子名称: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, Dual specificity protein kinase TTK | 著者 | Filippakopoulos, P, Soundararajan, M, Keates, T, Elkins, J.M, King, O, Fedorov, O, Picaud, S.S, Pike, A.C.W, Roos, A, Pilka, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2008-02-29 | 公開日 | 2008-03-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol., 6, 2010
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6FIB
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![BU of 6fib by Molmil](/molmil-images/mine/6fib) | Structure of human 4-1BB ligand | 分子名称: | Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor ligand superfamily member 9,4-1BBL -CH/CL fusion, Tumor necrosis factor ligand superfamily member 9,Uncharacterized protein | 著者 | Joseph, C, Claus, C, Ferrara, C, von Hirschheydt, T, Prince, C, Funk, D, Klein, C, Benz, J. | 登録日 | 2018-01-17 | 公開日 | 2019-03-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy. Sci Transl Med, 11, 2019
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2WNM
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![BU of 2wnm by Molmil](/molmil-images/mine/2wnm) | Solution structure of Gp2 | 分子名称: | GENE 2 | 著者 | Camara, B, Liu, M, Shadrinc, A, Liu, B, Simpson, P, Weinzierl, R, Severinovc, K, Cota, E, Matthews, S, Wigneshweraraj, S.R. | 登録日 | 2009-07-13 | 公開日 | 2010-02-16 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | T7 Phage Protein Gp2 Inhibits the Escherichia Coli RNA Polymerase by Antagonizing Stable DNA Strand Separation Near the Transcription Start Site. Proc.Natl.Acad.Sci.USA, 107, 2010
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2IHD
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![BU of 2ihd by Molmil](/molmil-images/mine/2ihd) | Crystal structure of Human Regulator of G-protein signaling 8, RGS8 | 分子名称: | CHLORIDE ION, Regulator of G-protein signaling 8 | 著者 | Turnbull, A.P, Papagrigoriou, E, Ugochukwu, E, Salah, E, Gileadi, C, Burgess, N, Bhatia, C, Gileadi, O, Bray, J, Elkins, J, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) | 登録日 | 2006-09-26 | 公開日 | 2006-11-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc.Natl.Acad.Sci.Usa, 105, 2008
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5NN8
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![BU of 5nn8 by Molmil](/molmil-images/mine/5nn8) | Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with acarbose | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Roig-Zamboni, V, Cobucci-Ponzano, B, Iacono, R, Ferrara, M.C, Germany, S, Parenti, G, Bourne, Y, Moracci, M. | 登録日 | 2017-04-08 | 公開日 | 2017-10-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structure of human lysosomal acid alpha-glucosidase-a guide for the treatment of Pompe disease. Nat Commun, 8, 2017
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5NN6
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![BU of 5nn6 by Molmil](/molmil-images/mine/5nn6) | Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with N-hydroxyethyl-1-deoxynojirimycin | 分子名称: | (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Roig-Zamboni, V, Cobucci-Ponzano, B, Iacono, R, Ferrara, M.C, Germany, S, Parenti, G, Bourne, Y, Moracci, M. | 登録日 | 2017-04-08 | 公開日 | 2017-10-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of human lysosomal acid alpha-glucosidase-a guide for the treatment of Pompe disease. Nat Commun, 8, 2017
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5NN4
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![BU of 5nn4 by Molmil](/molmil-images/mine/5nn4) | Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with N-acetyl-cysteine | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Roig-Zamboni, V, Cobucci-Ponzano, B, Iacono, R, Ferrara, M.C, Germany, S, Parenti, G, Bourne, Y, Moracci, M. | 登録日 | 2017-04-08 | 公開日 | 2017-10-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Structure of human lysosomal acid alpha-glucosidase-a guide for the treatment of Pompe disease. Nat Commun, 8, 2017
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5NN3
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![BU of 5nn3 by Molmil](/molmil-images/mine/5nn3) | Crystal structure of human lysosomal acid-alpha-glucosidase, GAA | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Roig-Zamboni, V, Cobucci-Ponzano, B, Iacono, R, Ferrara, M.C, Germany, S, Parenti, G, Bourne, Y, Moracci, M. | 登録日 | 2017-04-08 | 公開日 | 2017-10-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of human lysosomal acid alpha-glucosidase-a guide for the treatment of Pompe disease. Nat Commun, 8, 2017
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5NN5
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![BU of 5nn5 by Molmil](/molmil-images/mine/5nn5) | Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with 1-deoxynojirimycin | 分子名称: | 1,2-ETHANEDIOL, 1-DEOXYNOJIRIMYCIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Roig-Zamboni, V, Cobucci-Ponzano, B, Iacono, R, Ferrara, M.C, Germany, S, Parenti, G, Bourne, Y, Moracci, M. | 登録日 | 2017-04-08 | 公開日 | 2017-10-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of human lysosomal acid alpha-glucosidase-a guide for the treatment of Pompe disease. Nat Commun, 8, 2017
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4Z8E
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![BU of 4z8e by Molmil](/molmil-images/mine/4z8e) | TEAD DBD mutant -deltaL1 | 分子名称: | Transcriptional enhancer factor TEF-1 | 著者 | Lee, D.-S, Albarado, D.C, Vonrhein, C, Raman, C.S, Veeraraghavan, S. | 登録日 | 2015-04-08 | 公開日 | 2016-04-13 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | 主引用文献 | A Potential Structural Switch for Regulating DNA-Binding by TEAD Transcription Factors. J.Mol.Biol., 428, 2016
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1ZL7
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![BU of 1zl7 by Molmil](/molmil-images/mine/1zl7) | Crystal structure of catalytically-active phospholipase A2 with bound calcium | 分子名称: | CALCIUM ION, GLYCEROL, hypotensive phospholipase A2 | 著者 | Murakami, M.T, Cintra, A.C, Gabdoulkhakov, A, Genov, N, Betzel, C, Arni, R.K. | 登録日 | 2005-05-05 | 公開日 | 2006-04-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Insights into metal ion binding in phospholipases A(2): ultra high-resolution crystal structures of an acidic phospholipase A(2) in the Ca(2+) free and bound states. Biochimie, 88, 2006
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1ZLB
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![BU of 1zlb by Molmil](/molmil-images/mine/1zlb) | Crystal structure of catalytically-active phospholipase A2 in the absence of calcium | 分子名称: | hypotensive phospholipase A2 | 著者 | Murakami, M.T, Cintra, A.C, Gabdoulkhakov, A, Genov, N, Betzel, C, Arni, R.K. | 登録日 | 2005-05-05 | 公開日 | 2006-04-25 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (0.97 Å) | 主引用文献 | Insights into metal ion binding in phospholipases A(2): ultra high-resolution crystal structures of an acidic phospholipase A(2) in the Ca(2+) free and bound states. Biochimie, 88, 2006
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1Z76
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![BU of 1z76 by Molmil](/molmil-images/mine/1z76) | Crystal structure of an acidic phospholipase A2 (BthA-I) from Bothrops jararacussu venom complexed with p-bromophenacyl bromide | 分子名称: | p-Bromophenacyl bromide, phospholipase A2 | 著者 | Magro, A.J, Takeda, A.A, Soares, A.M, Fontes, M.R. | 登録日 | 2005-03-24 | 公開日 | 2006-03-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure of BthA-I complexed with p-bromophenacyl bromide: possible correlations with lack of pharmacological activity. Acta Crystallogr.,Sect.D, 61, 2005
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