5NN3

Crystal structure of human lysosomal acid-alpha-glucosidase, GAA

Summary for 5NN3

• Entry DOI: 10.2210/pdb5nn3/pdb
• Descriptor: Lysosomal alpha-glucosidase, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: glycoside hydrolase, lysosome, glycogen catabolism, pompe disease, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 101294.13

Authors

Roig-Zamboni, V.,Cobucci-Ponzano, B.,Iacono, R.,Ferrara, M.C.,Germany, S.,Parenti, G.,Bourne, Y.,Moracci, M. (deposition date: 2017-04-08, release date: 2017-10-25, Last modification date: 2024-01-17)

• Primary citation: Roig-Zamboni, V.,Cobucci-Ponzano, B.,Iacono, R.,Ferrara, M.C.,Germany, S.,Bourne, Y.,Parenti, G.,Moracci, M.,Sulzenbacher, G.; Structure of human lysosomal acid alpha-glucosidase-a guide for the treatment of Pompe disease.; Nat Commun, 8:1111-1111, 2017; PubMed: 29061980; DOI: 10.1038/s41467-017-01263-3

Experimental method

X-RAY DIFFRACTION (1.9 Å)