PDB: 159 件ウェブページステータス検索Chemie searchBIRD

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7R5L	Crystal structure of YTHDF2 with compound YLI_DC1_015 分子名称: 3,6-dimethyl-2~{H}-1,2,4-triazin-5-one, SULFATE ION, YTH domain-containing family protein 2 著者 Nachawati, R, Nai, F, Li, Y, Caflisch, A. 登録日 2022-02-10 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7R5F	Crystal structure of YTHDF2 with compound YLI_DF_012 分子名称: 5-azanyl-6-methyl-1~{H}-pyrimidine-2,4-dione, CHLORIDE ION, SULFATE ION, ... 著者 Nai, F, Li, Y, Caflisch, A. 登録日 2022-02-10 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7QL7	Crystal structure of YTHDF1 YTH domain in complex with the ebsulfur derivative compound 9 分子名称: 1,2-ETHANEDIOL, THIOCYANATE ION, YTH domain-containing family protein 1, ... 著者 Dalle Vedove, A, Cazzanelli, G, Quattrone, A, Provenzani, A, Lolli, G. 登録日 2021-12-19 公開日 2022-11-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6 -Methyladenosine-Modified RNAs. Acs Pharmacol Transl Sci, 5, 2022
7QKN	Crystal structure of YTHDF1 YTH domain in complex with the ebsulfur derivative compound 7 分子名称: 1,2-ETHANEDIOL, THIOCYANATE ION, YTH domain-containing family protein 1, ... 著者 Dalle Vedove, A, Cazzanelli, G, Quattrone, A, Provenzani, A, Lolli, G. 登録日 2021-12-18 公開日 2022-11-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6 -Methyladenosine-Modified RNAs. Acs Pharmacol Transl Sci, 5, 2022
7PO6	Xist (m6A)UCG tetraloop RNA bound to the YTH domain of YTHDC1 分子名称: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, Isoform 2 of YTH domain-containing protein 1, ... 著者 Jones, A.N, Mourao, A, Sattler, M. 登録日 2021-09-08 公開日 2022-03-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Structural effects of m6A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1. Nucleic Acids Res., 50, 2022
7PJQ	Crystal structure of YTHDC1 with compound T96 分子名称: DI(HYDROXYETHYL)ETHER, SULFATE ION, YTH domain-containing protein 1, ... 著者 Bedi, R.K, Huang, D, Caflisch, A. 登録日 2021-08-24 公開日 2021-10-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
7PJP	Crystal structure of YTHDC1 with compound DHU_DC1_226 分子名称: 5-(furan-2-yl)-N-methyl-1H-pyrazole-3-carboxamide, SULFATE ION, YTH domain-containing protein 1 著者 Bedi, R.K, Huang, D, Caflisch, A. 登録日 2021-08-24 公開日 2021-10-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
7PJB	Crystal structure of YTHDC1 with compound PSI_DC1_004 分子名称: (R)-homoproline, GLYCEROL, SULFATE ION, ... 著者 Bedi, R.K, Huang, D, Caflisch, A. 登録日 2021-08-23 公開日 2021-10-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
7PJA	Crystal structure of YTHDC1 with compound PSI_DC1_002 分子名称: 6-methyl-3H-pyridin-2-one, GLYCEROL, SULFATE ION, ... 著者 Bedi, R.K, Huang, D, Caflisch, A. 登録日 2021-08-23 公開日 2021-10-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
7PJ9	Crystal structure of YTHDC1 with compound DHU_DC1_232 分子名称: 5-bromanyl-N-methyl-1H-indazole-3-carboxamide, SULFATE ION, YTH domain-containing protein 1 著者 Bedi, R.K, Huang, D, Caflisch, A. 登録日 2021-08-23 公開日 2021-10-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
7PJ8	Crystal structure of YTHDC1 with compound DHU_DC1_225 分子名称: N-methyl-1H-indole-4-carboxamide, SULFATE ION, YTH domain-containing protein 1 著者 Bedi, R.K, Huang, D, Caflisch, A. 登録日 2021-08-23 公開日 2021-10-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
7PJ7	Crystal structure of YTHDC1 with compound DHU_DC1_222 分子名称: N-methyl-3-(5-methylthiophen-2-yl)-1H-pyrazole-5-carboxamide, SULFATE ION, YTH domain-containing protein 1 著者 Bedi, R.K, Huang, D, Caflisch, A. 登録日 2021-08-23 公開日 2021-10-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
7PCU	Crystal structure of YTHDF1 YTH domain in complex with ebselen 分子名称: N-phenyl-2-selanylbenzamide, YTH domain-containing family protein 1 著者 Dalle Vedove, A, Cazzanelli, G, Quattrone, A, Provenzani, A, Lolli, G. 登録日 2021-08-04 公開日 2022-12-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6 -Methyladenosine-Modified RNAs. Acs Pharmacol Transl Sci, 5, 2022
7P8F	Crystal structure of YTHDC1 with compound YLI_DC1_008 分子名称: SULFATE ION, YTH domain-containing protein 1, ~{N},3-dimethyl-1~{H}-pyrazolo[4,3-d]pyrimidin-7-amine 著者 Bedi, R.K, Li, Y, Caflisch, A. 登録日 2021-07-21 公開日 2021-10-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
7P8B	Crystal structure of YTHDC1 with compound YLI_DC1_006 分子名称: 9-cyclopropyl-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1 著者 Bedi, R.K, Li, Y, Dolbois, A, Caflisch, A. 登録日 2021-07-21 公開日 2021-10-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
7P8A	Crystal structure of YTHDC1 with compound YLI_DC1_003 分子名称: SULFATE ION, YTH domain-containing protein 1, ~{N},9-dimethylpurin-6-amine 著者 Bedi, R.K, Li, Y, Dolbois, A, Caflisch, A. 登録日 2021-07-21 公開日 2021-10-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
7P88	Crystal structure of YTHDC1 with compound YLI_DC1_002 分子名称: 2-chloranyl-~{N}-methyl-9~{H}-purin-6-amine, SULFATE ION, YTH domain-containing protein 1 著者 Bedi, R.K, Li, Y, Dolbois, A, Caflisch, A. 登録日 2021-07-21 公開日 2021-10-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
7P87	Crystal structure of YTHDC1 with compound YLI_DC1_001 分子名称: N-methyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide, SULFATE ION, YTH domain-containing protein 1 著者 Bedi, R.K, Li, Y, Dolbois, A, Caflisch, A. 登録日 2021-07-21 公開日 2021-10-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
7NJC	Crystal structure of the Toxoplasma CPSF4 YTH-domain in complex with a 7 mer m6A-modified RNA 分子名称: 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, N-methyladenosine, RNA (5'-R(*(6MZ)P*CP*A)-3'), ... 著者 Swale, C, Bowler, M.W. 登録日 2021-02-16 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma . Elife, 10, 2021
7NH2	Crystal structure of Toxoplasma CPSF4-YTH domain bound to m6A 分子名称: TETRAETHYLENE GLYCOL, Zinc finger (CCCH type) motif-containing protein, ~{N},9-dimethylpurin-6-amine 著者 Swale, C, Bowler, M.W. 登録日 2021-02-09 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma . Elife, 10, 2021
7NG2	Crystal structure of Toxoplasma CPSF4-YTH domain in apo form 分子名称: ISOPROPYL ALCOHOL, Zinc finger (CCCH type) motif-containing protein 著者 Swale, C, Bowler, M.W. 登録日 2021-02-08 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma . Elife, 10, 2021
7L4Y	YTH Domain of Human YTHDC1 with dsDNA Comprising Single N6mA joined by Two Six-bp DNA Duplexes in P212121 Crystal 分子名称: 1,2-ETHANEDIOL, YTH domain-containing protein 1, ssDNA 13mer 著者 Horton, J.R, Cheng, X. 登録日 2020-12-21 公開日 2021-11-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions. Nucleic Acids Res., 49, 2021
7L4X	YTH Domain of Human YTHDC1 with dsDNA Comprising Single N6mA joined by two six-bp DNA duplexes in P3221 Crystal 分子名称: 1,2-ETHANEDIOL, YTH domain-containing protein 1, ssDNA w/N6A 著者 Horton, J.R, Cheng, X. 登録日 2020-12-21 公開日 2021-11-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions. Nucleic Acids Res., 49, 2021
7BIK	Crystal structure of YTHDF2 in complex with m6Am 分子名称: (2~{R},3~{S},4~{R},5~{R})-2-(hydroxymethyl)-4-methoxy-5-[6-(methylamino)purin-9-yl]oxolan-3-ol, GLYCEROL, SULFATE ION, ... 著者 Wang, X, Caflisch, A. 登録日 2021-01-12 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of YTHDF2 in complex with m6Am To Be Published
7A1V	Crystal structure of YTHDF2 in complex with m1A 分子名称: 6-AMINO-1-METHYLPURINE, GLYCEROL, SULFATE ION, ... 著者 Wang, X, Caflisch, A. 登録日 2020-08-14 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of YTHDF2 in complex with m1A To Be Published

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