7L4X

YTH Domain of Human YTHDC1 with dsDNA Comprising Single N6mA joined by two six-bp DNA duplexes in P3221 Crystal

Summary for 7L4X

• Entry DOI: 10.2210/pdb7l4x/pdb
• Descriptor: YTH domain-containing protein 1, ssDNA w/N6A, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: n6-methyladenine binding protein domain, ssdna, dna binding protein, protein-dna complex, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 23000.66

Authors

Horton, J.R.,Cheng, X. (deposition date: 2020-12-21, release date: 2021-11-03, Last modification date: 2023-10-18)

• Primary citation: Yu, D.,Horton, J.R.,Yang, J.,Hajian, T.,Vedadi, M.,Sagum, C.A.,Bedford, M.T.,Blumenthal, R.M.,Zhang, X.,Cheng, X.; Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.; Nucleic Acids Res., 49:11629-11642, 2021; PubMed: 34086966; DOI: 10.1093/nar/gkab460

Experimental method

X-RAY DIFFRACTION (1.79 Å)