7R5L

Crystal structure of YTHDF2 with compound YLI_DC1_015

Summary for 7R5L

Entry DOI	10.2210/pdb7r5l/pdb
Descriptor	YTH domain-containing family protein 2, 3,6-dimethyl-2~{H}-1,2,4-triazin-5-one, SULFATE ION, ... (4 entities in total)
Functional Keywords	epitranscriptomic reader m6a reader, rna binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	19973.29
Authors	Nachawati, R.,Nai, F.,Li, Y.,Caflisch, A. (deposition date: 2022-02-10, release date: 2022-03-02, Last modification date: 2024-01-31)
Primary citation	Nai, F.,Nachawati, R.,Zalesak, F.,Wang, X.,Li, Y.,Caflisch, A. Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13:1500-1509, 2022 Cited by PubMed: 36110386 DOI: 10.1021/acsmedchemlett.2c00303 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation