7QKN

Crystal structure of YTHDF1 YTH domain in complex with the ebsulfur derivative compound 7

Summary for 7QKN

Entry DOI	10.2210/pdb7qkn/pdb
Related	7PCU
Descriptor	YTH domain-containing family protein 1, ~{N}-[2-(diethylamino)ethyl]-2-sulfanyl-benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	mrna binding and stability, rna binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	47103.45
Authors	Dalle Vedove, A.,Cazzanelli, G.,Quattrone, A.,Provenzani, A.,Lolli, G. (deposition date: 2021-12-18, release date: 2022-11-23, Last modification date: 2024-01-31)
Primary citation	Micaelli, M.,Dalle Vedove, A.,Cerofolini, L.,Vigna, J.,Sighel, D.,Zaccara, S.,Bonomo, I.,Poulentzas, G.,Rosatti, E.F.,Cazzanelli, G.,Alunno, L.,Belli, R.,Peroni, D.,Dassi, E.,Murakami, S.,Jaffrey, S.R.,Fragai, M.,Mancini, I.,Lolli, G.,Quattrone, A.,Provenzani, A. Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6 -Methyladenosine-Modified RNAs. Acs Pharmacol Transl Sci, 5:872-891, 2022 Cited by PubMed: 36268123 DOI: 10.1021/acsptsci.2c00008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation