5HMW
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![BU of 5hmw by Molmil](/molmil-images/mine/5hmw) | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 5 | 分子名称: | 2,2'-biphenyl-3,5-diyldiacetic acid, RNA-directed RNA polymerase NS5, ZINC ION | 著者 | Noble, C.G. | 登録日 | 2016-01-17 | 公開日 | 2016-03-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59, 2016
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5I3P
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![BU of 5i3p by Molmil](/molmil-images/mine/5i3p) | DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 27 | 分子名称: | 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, Genome polyprotein, ZINC ION | 著者 | Noble, C.G. | 登録日 | 2016-02-10 | 公開日 | 2016-07-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling Plos Pathog., 12, 2016
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5I3Q
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![BU of 5i3q by Molmil](/molmil-images/mine/5i3q) | DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 29 | 分子名称: | 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide, Genome polyprotein, ZINC ION | 著者 | Noble, C.G. | 登録日 | 2016-02-10 | 公開日 | 2016-07-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling Plos Pathog., 12, 2016
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5IQ6
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![BU of 5iq6 by Molmil](/molmil-images/mine/5iq6) | Crystal structure of Dengue virus serotype 3 RNA dependent RNA polymerase bound to HeE1-2Tyr, a new pyridobenzothizole inhibitor | 分子名称: | N-[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carbonyl]-L-tyrosine, RNA dependent RNA polymerase, ZINC ION | 著者 | Tarantino, D, Mastrangelo, E, Milani, M. | 登録日 | 2016-03-10 | 公開日 | 2016-10-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res., 134, 2016
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6IZZ
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![BU of 6izz by Molmil](/molmil-images/mine/6izz) | |
6J00
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![BU of 6j00 by Molmil](/molmil-images/mine/6j00) | |
6KR2
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![BU of 6kr2 by Molmil](/molmil-images/mine/6kr2) | Crystal structure of Dengue virus nonstructural protein NS5 (form 1) | 分子名称: | Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | 著者 | Wu, J, Lu, G, Ye, H.Q, Gong, P. | 登録日 | 2019-08-20 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | 主引用文献 | A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase. Plos Pathog., 16, 2020
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6KR3
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![BU of 6kr3 by Molmil](/molmil-images/mine/6kr3) | Crystal structure of Dengue virus nonstructural protein NS5 (form 2) | 分子名称: | GLYCEROL, Genome polyprotein, IODIDE ION, ... | 著者 | Wu, J, Lu, G, Ye, H.Q, Gong, P. | 登録日 | 2019-08-20 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.931 Å) | 主引用文献 | A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase. Plos Pathog., 16, 2020
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6LD2
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![BU of 6ld2 by Molmil](/molmil-images/mine/6ld2) | Zika NS5 polymerase domain | 分子名称: | (1S,2S,4S,5R)-2,4-dimethoxy-5-thiophen-2-yl-cyclohexane-1-carboxylic acid, RNA-directed RNA polymerase NS5, ZINC ION | 著者 | El Sahili, A, Lescar, J. | 登録日 | 2019-11-20 | 公開日 | 2020-08-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
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6LD1
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![BU of 6ld1 by Molmil](/molmil-images/mine/6ld1) | Zika NS5 polymerase domain | 分子名称: | 1,2-ETHANEDIOL, RNA-directed RNA polymerase NS5, ZINC ION | 著者 | El Sahili, A, Lescar, J. | 登録日 | 2019-11-20 | 公開日 | 2020-08-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
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6LD5
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![BU of 6ld5 by Molmil](/molmil-images/mine/6ld5) | Zika NS5 polymerase domain | 分子名称: | 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, RNA-directed RNA polymerase NS5, ZINC ION, ... | 著者 | El Sahili, A, Lescar, J. | 登録日 | 2019-11-20 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
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6LD3
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![BU of 6ld3 by Molmil](/molmil-images/mine/6ld3) | Zika NS5 polymerase domain | 分子名称: | 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, RNA-directed RNA polymerase NS5, ZINC ION, ... | 著者 | El Sahili, A, Lescar, J. | 登録日 | 2019-11-20 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
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6LD4
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![BU of 6ld4 by Molmil](/molmil-images/mine/6ld4) | Zika NS5 polymerase domain | 分子名称: | 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, 3-methoxybenzenesulfonamide, RNA-directed RNA polymerase NS5, ... | 著者 | El Sahili, A, Lescar, J. | 登録日 | 2019-11-20 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
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6IZY
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![BU of 6izy by Molmil](/molmil-images/mine/6izy) | |
6IZX
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![BU of 6izx by Molmil](/molmil-images/mine/6izx) | The RNA-dependent RNA polymerase domain of dengue 2 NS5, bound with RK-0404678 | 分子名称: | 2-oxo-2H-1,3-benzoxathiol-5-yl acetate, COBALT (II) ION, Genome polyprotein, ... | 著者 | Shimizu, H, Sekine, S. | 登録日 | 2018-12-20 | 公開日 | 2019-12-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. Plos Negl Trop Dis, 13, 2019
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6UX2
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![BU of 6ux2 by Molmil](/molmil-images/mine/6ux2) | |
8T12
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![BU of 8t12 by Molmil](/molmil-images/mine/8t12) | |
8T13
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![BU of 8t13 by Molmil](/molmil-images/mine/8t13) | |
8GZR
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![BU of 8gzr by Molmil](/molmil-images/mine/8gzr) | Cryo-EM structure of the the NS5-NS3 RNA-elongation complex | 分子名称: | CYTIDINE-5'-DIPHOSPHATE, Genome polyprotein, MANGANESE (II) ION, ... | 著者 | Osawa, T, Ehara, H, Sekine, S. | 登録日 | 2022-09-27 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-23 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structures of dengue virus RNA replicase complexes. Mol.Cell, 83, 2023
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8GZQ
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![BU of 8gzq by Molmil](/molmil-images/mine/8gzq) | Cryo-EM structure of the NS5-NS3-SLA complex | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Genome polyprotein, RNA, ... | 著者 | Osawa, T, Ehara, H, Sekine, S. | 登録日 | 2022-09-27 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-23 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structures of dengue virus RNA replicase complexes. Mol.Cell, 83, 2023
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6WCZ
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![BU of 6wcz by Molmil](/molmil-images/mine/6wcz) | CryoEM structure of full-length ZIKV NS5-hSTAT2 complex | 分子名称: | Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION | 著者 | Boxiao, W, Stephanie, T, Kang, Z, Maria, T.S, Jian, F, Jiuwei, L, Linfeng, G, Wendan, R, Yanxiang, C, Ethan, C.V, HeaJin, H, Matthew, J.E, Sean, E.O, Adolfo, G.S, Hong, Z, Rong, H, Jikui, S. | 登録日 | 2020-03-31 | 公開日 | 2020-07-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis for STAT2 suppression by flavivirus NS5. Nat.Struct.Mol.Biol., 27, 2020
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8CXH
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![BU of 8cxh by Molmil](/molmil-images/mine/8cxh) | Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy | 分子名称: | Ankyrin repeat family A protein 2,Envelope E protein, C10 heavy chain, C10 light chain, ... | 著者 | Liu, W, Zhang, X.K, Gong, D.Y, Dai, X.H, Sharma, A, Zhang, T.H, Rey, F, Zhou, Z.H. | 登録日 | 2022-05-21 | 公開日 | 2023-06-07 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy To Be Published
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8CXI
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![BU of 8cxi by Molmil](/molmil-images/mine/8cxi) | Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy | 分子名称: | A11 heavy chain, A11 light chain, Ankyrin repeat family A protein 2,Envelope E protein, ... | 著者 | Liu, W, Zhang, X.K, Gong, D.Y, Dai, X.H, Sharma, A, Zhang, T.H, Rey, F, Zhou, Z.H. | 登録日 | 2022-05-21 | 公開日 | 2023-06-07 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy To Be Published
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8CXG
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![BU of 8cxg by Molmil](/molmil-images/mine/8cxg) | Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy | 分子名称: | Ankyrin repeat family A protein 2,Envelope E protein, C8 scFv heavy chain, C8 scFv light chain, ... | 著者 | Liu, W, Zhang, X.K, Gong, D.Y, Dai, X.H, Sharma, A, Zhang, T.H, Rey, F, Zhou, Z.H. | 登録日 | 2022-05-21 | 公開日 | 2023-06-07 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy To Be Published
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