5IQ6
Crystal structure of Dengue virus serotype 3 RNA dependent RNA polymerase bound to HeE1-2Tyr, a new pyridobenzothizole inhibitor
Summary for 5IQ6
Entry DOI | 10.2210/pdb5iq6/pdb |
Descriptor | RNA dependent RNA polymerase, ZINC ION, N-[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carbonyl]-L-tyrosine, ... (4 entities in total) |
Functional Keywords | rna dependent rna polymerase, hydrolase |
Biological source | Dengue virus 3 |
Cellular location | Virion membrane ; Multi-pass membrane protein : Q6DLV0 |
Total number of polymer chains | 1 |
Total formula weight | 73582.53 |
Authors | Tarantino, D.,Mastrangelo, E.,Milani, M. (deposition date: 2016-03-10, release date: 2016-10-05, Last modification date: 2016-10-12) |
Primary citation | Tarantino, D.,Cannalire, R.,Mastrangelo, E.,Croci, R.,Querat, G.,Barreca, M.L.,Bolognesi, M.,Manfroni, G.,Cecchetti, V.,Milani, M. Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res., 134:226-235, 2016 Cited by PubMed: 27649989DOI: 10.1016/j.antiviral.2016.09.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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