5IQ6
Crystal structure of Dengue virus serotype 3 RNA dependent RNA polymerase bound to HeE1-2Tyr, a new pyridobenzothizole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RNA dependent RNA polymerase | polymer | 628 | 72869.0 | 1 | UniProt (Q6DLV0) Pfam (PF00972) Pfam (PF20483) UniProt (by SIFTS) (Q6YMS4) | Dengue virus 3 | |
| 2 | B, C (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D (A) | N-[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carbonyl]-L-tyrosine | non-polymer | 582.7 | 1 | Chemie (6CJ) | |||
| 4 | E (A) | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A: 273 - 900 (UniProt: Q6DLV0)
| PDB | External Database | Details |
|---|---|---|
| Glu 374 | Gly 2864 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 72869.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 713.5 | |
| All* | Total formula weight | 73582.5 |
