PDB: 82 件ウェブページステータス検索Chemie searchBIRD

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1CZA	MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP 分子名称: 6-O-phosphono-alpha-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, HEXOKINASE TYPE I, ... 著者 Aleshin, A.E, Liu, X, Kirby, C, Bourenkov, G.P, Bartunik, H.D, Fromm, H.J, Honzatko, R.B. 登録日 1999-09-01 公開日 2000-03-06 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation. J.Mol.Biol., 296, 2000
6JJ8	Crystal structure of OsHXK6-ATP-Mg2+ complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... 著者 He, C, Wei, P, Chen, J, Wang, H, Wan, Y, Zhou, J, Zhu, Y, Huang, W, Yin, L. 登録日 2019-02-25 公開日 2019-07-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of OsHXK6-ATP-Mg2+ complex To Be Published
6JJ7	Crystal structure of OsHXK6-Glc complex 分子名称: Rice hexokinase 6, beta-D-glucopyranose 著者 He, C, Wei, P, Chen, J, Wang, H, Wan, Y, Zhou, J, Zhu, Y, Huang, W, Yin, L. 登録日 2019-02-25 公開日 2019-07-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of OsHXK6-Glc complex To Be Published
6JJ4	Crystal structure of OsHXK6-apo form 分子名称: Hexokinase-6 著者 He, C, Wei, P, Chen, J, Wang, H, Wan, Y, Zhou, J, Zhu, Y, Huang, W, Yin, L. 登録日 2019-02-25 公開日 2019-07-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of OsHXK6-apo To Be Published
6JJ9	Crystal structure of OsHXK6-Glc-ATP-Mg2+ complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, Hexokinase-6, MAGNESIUM ION, ... 著者 He, C, Wei, P, Chen, J, Wang, H, Wan, Y, Zhou, J, Zhu, Y, Huang, W, Yin, L. 登録日 2019-02-25 公開日 2019-07-03 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of OsHXK6-Glc-ATP-Mg2+ complex To Be Published
1HKG	STRUCTURAL DYNAMICS OF YEAST HEXOKINASE DURING CATALYSIS 分子名称: HEXOKINASE A 著者 Bennett Jr, W.S, Steitz, T.A. 登録日 1980-12-22 公開日 1981-02-26 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural dynamics of yeast hexokinase during catalysis. Philos.Trans.R.Soc.London,Ser.B, 293, 1981
1HKC	RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND PHOSPHATE 分子名称: D-GLUCOSE 6-PHOSPHOTRANSFERASE, PHOSPHATE ION, POTASSIUM ION, ... 著者 Aleshin, A.E, Honzatko, R.B. 登録日 1998-07-01 公開日 1998-11-11 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate. J.Mol.Biol., 282, 1998
4LC9	Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein 分子名称: 6-O-phosphono-beta-D-fructofuranose, Glucokinase, Glucokinase regulatory protein, ... 著者 Beck, T, Miller, B.G. 登録日 2013-06-21 公開日 2013-09-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structural basis for regulation of human glucokinase by glucokinase regulatory protein. Biochemistry, 52, 2013
4MLE	Human Glucokinase in Complex with Novel Amino Thiazole Activator 分子名称: 3-(benzyloxy)-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine, Glucokinase, alpha-D-glucopyranose 著者 Voegtli, W.C. 登録日 2013-09-06 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Identification of a New Class of Glucokinase Activators through Structure-Based Design. J.Med.Chem., 56, 2013
4MLH	Human Glucokinase in Complex with a Novel Amino Thiazole Allosteric Activator 分子名称: 3-(benzyloxy)-5-methyl-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine, Glucokinase, alpha-D-glucopyranose 著者 Voegtli, W.C. 登録日 2013-09-06 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Identification of a New Class of Glucokinase Activators through Structure-Based Design. J.Med.Chem., 56, 2013
3F9M	Human pancreatic glucokinase in complex with glucose and activator showing a mobile flap 分子名称: 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE, Glucokinase, alpha-D-glucopyranose 著者 Petit, P, Gluais, L, Lagarde, A, Vuillard, L, Boutin, J.A, Ferry, G. 登録日 2008-11-14 公開日 2008-12-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The active conformation of human glucokinase is not altered by allosteric activators Acta Crystallogr.,Sect.D, 67, 2011
4L3Q	Crystal structure of glucokinase-activator complex 分子名称: 6-{3-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}pyridin-2(1H)-one, Glucokinase, alpha-D-glucopyranose 著者 Gajiwala, K.S, Filipski, K.J. 登録日 2013-06-06 公開日 2013-07-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif. Bioorg.Med.Chem.Lett., 23, 2013
3FR0	Human glucokinase in complex with 2-amino benzamide activator 分子名称: 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide, Glucokinase, SODIUM ION, ... 著者 Kamata, K. 登録日 2009-01-08 公開日 2009-02-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators Bioorg.Med.Chem.Lett., 19, 2009
3FGU	Catalytic complex of Human Glucokinase 分子名称: Glucokinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Petit, P, Lagarde, A, Boutin, J.A, Ferry, G, Vuillard, L. 登録日 2008-12-08 公開日 2009-12-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 The active conformation of human glucokinase is not altered by allosteric activators Acta Crystallogr.,Sect.D, 67, 2011
4NO7	Human Glucokinase in complex with a nanomolar activator. 分子名称: (2R)-2-[3-chloro-4-(methylsulfonyl)phenyl]-3-[(1R)-3-oxocyclopentyl]-N-(pyrazin-2-yl)propanamide, Glucokinase, alpha-D-glucopyranose 著者 Petit, P, Ferry, G, Antoine, M, Boutin, J.A, Kotschy, A, Perron-Sierra, F, Mamelli, L, Vuillard, L. 登録日 2013-11-19 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The active conformation of human glucokinase is not altered by allosteric activators. Acta Crystallogr. D Biol. Crystallogr., 67, 2011
3H1V	Human glucokinase in complex with a synthetic activator 分子名称: 1-({5-[4-(methylsulfonyl)phenoxy]-2-pyridin-2-yl-1H-benzimidazol-6-yl}methyl)pyrrolidine-2,5-dione, Glucokinase, SODIUM ION, ... 著者 Kamata, K, Takahashi, K. 登録日 2009-04-14 公開日 2009-10-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. Bioorg.Med.Chem., 17, 2009
3GOI	Human glucokinase in complex with a synthetic activator 分子名称: 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide, Glucokinase, alpha-D-glucopyranose 著者 Kamata, K, Mitsuya, M. 登録日 2009-03-19 公開日 2009-04-28 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators Bioorg.Med.Chem.Lett., 19, 2009
4FOE	Crystal Structure of recombinant human Hexokinase type I with Mannose 6-Phosphate 分子名称: 6-O-phosphono-beta-D-mannopyranose, CITRIC ACID, Hexokinase-1, ... 著者 Shen, L, Honzatko, R.B. 登録日 2012-06-20 公開日 2013-07-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Inhibitor Sites of Unequal Affinity Linked by Binding Synergism in Mutant Forms of Recombinant Human Hexokinase Type-I to be published
4ISE	Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-N-(1,3-thiazol-2-yl)propanamide 分子名称: (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-N-(1,3-thiazol-2-yl)propanamide, Glucokinase, IODIDE ION, ... 著者 Hosfield, D, Skene, R.J. 登録日 2013-01-16 公開日 2013-03-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Design, synthesis and SAR of novel glucokinase activators. Bioorg.Med.Chem.Lett., 23, 2013
4IWV	Crystals structure of Human Glucokinase in complex with small molecule activator 分子名称: (2S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(5-chloropyridin-2-yl)-3-(2-hydroxyethoxy)propanamide, Glucokinase isoform 3, SODIUM ION, ... 著者 Ogg, D.J, Hargreaves, D, Gerhardt, S, Flavell, L, McAlister, M. 登録日 2013-01-24 公開日 2013-04-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets the discovery of AZD3651 and AZD9485 To be Published
4ISG	Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide 分子名称: (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide, Glucokinase, IODIDE ION, ... 著者 Hosfield, D, Skene, R.J. 登録日 2013-01-16 公開日 2013-03-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.645 Å) 主引用文献 Design, synthesis and SAR of novel glucokinase activators. Bioorg.Med.Chem.Lett., 23, 2013
4JAX	Crystal structure of dimeric KlHxk1 in crystal form X 分子名称: GLYCEROL, Hexokinase, PHOSPHATE ION 著者 Kuettner, E.B, Strater, N, Kettner, K, Otto, A, Lilie, H, Golbik, R.P, Kriegel, T.M. 登録日 2013-02-19 公開日 2013-05-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 In vivo phosphorylation and in vitro autophosphorylation-inactivation of Kluyveromyces lactis hexokinase KlHxk1. Biochem.Biophys.Res.Commun., 435, 2013
4ISF	Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1,3-thiazol-2-yl)propanamide 分子名称: (2S)-3-cyclohexyl-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1,3-thiazol-2-yl)propanamide, Glucokinase, IODIDE ION, ... 著者 Hosfield, D, Skene, R.J. 登録日 2013-01-16 公開日 2013-03-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Design, synthesis and SAR of novel glucokinase activators. Bioorg.Med.Chem.Lett., 23, 2013
4IXC	Crystal structure of Human Glucokinase in complex with a small molecule activator. 分子名称: (2S)-2-{[1-(3-chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(5-methylpyridin-2-yl)-3-(propan-2-yloxy)propanamide, Glucokinase isoform 3, SODIUM ION, ... 著者 Ogg, D.J, Hargreaves, D, Gerhardt, S. 登録日 2013-01-25 公開日 2013-04-24 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Matched triplicate design sets in the optimisation of glucokinase activators maximising medicinal chemistry information content To be Published
3O1B	CRYSTAL STRUCTURE OF DIMERIC KLHXK1 IN CRYSTAL FORM II 分子名称: Hexokinase 著者 Kuettner, E.B, Kettner, K, Keim, A, Kriegel, T.M, Strater, N. 登録日 2010-07-21 公開日 2010-10-13 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structure of Hexokinase KlHxk1 of Kluyveromyces lactis: A MOLECULAR BASIS FOR UNDERSTANDING THE CONTROL OF YEAST HEXOKINASE FUNCTIONS VIA COVALENT MODIFICATION AND OLIGOMERIZATION. J.Biol.Chem., 285, 2010

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