PDB: 593 件ウェブページステータス検索Chemie searchBIRD

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8SXS	Crystal structure of a Nudix hydrolase effector from Magnaporthe oryzae 分子名称: Nudix hydrolase domain-containing protein 著者 McCombe, C.L, Ericsson, D.J, Williams, S.J. 登録日 2023-05-23 公開日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Plant pathogenic fungi hijack phosphate starvation signaling with conserved enzymatic effectors Biorxiv, 2023
3QSJ	Crystal structure of NUDIX hydrolase from Alicyclobacillus acidocaldarius 分子名称: CALCIUM ION, GLYCEROL, NUDIX hydrolase 著者 Michalska, K, Wu, R, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2011-02-21 公開日 2011-04-13 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of NUDIX hydrolase from Alicyclobacillus acidocaldarius To be Published
8A0S	MTH1 in complex with TH013350 分子名称: 4-[(2-chlorophenyl)methylsulfanyl]-5~{H}-pyrimidin-2-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION 著者 Liu, H, Scaletti, E, Stenmark, P. 登録日 2022-05-30 公開日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 MTH1 in complex with TH013350 To Be Published
8A3A	MTH1 in complex with TH013074 分子名称: 4-(4-methylphenyl)-1~{H}-quinazolin-2-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION 著者 Liu, H, Scaletti, E, Stenmark, P. 登録日 2022-06-07 公開日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 MTH1 in complex with TH013074 To Be Published
8A34	MTH1 in complex with TH013071 分子名称: 5-(2-phenylphenyl)-1H-pyrimidine-2,4-dione, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ... 著者 Liu, H, Scaletti, E, Stenmark, P. 登録日 2022-06-07 公開日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 MTH1 in complex with TH013071 To Be Published
8A07	MTH1 in complex with TH001969 分子名称: 1~{H}-quinazoline-2,4-dione, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION 著者 Scaletti, E.R, Narwal, M, Stenmark, P. 登録日 2022-05-26 公開日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 MTH1 in complex with TH001969 To Be Published
8A0T	MTH1 in complex with TH012532 分子名称: 5-(phenylmethyl)pyrimidine-2,4-diol, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ... 著者 Scaletti, E, Stenmark, P. 登録日 2022-05-30 公開日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 MTH1 in complex with TH012532 To Be Published
3I7V	Crystal structure of AP4A hydrolase complexed with AP4A (ATP) (aq_158) from Aquifex aeolicus Vf5 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, AP4A hydrolase, ... 著者 Jeyakanthan, J, Kanaujia, S.P, Nakagawa, N, Sekar, K, Kuramitsu, S, Shinkai, A, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2009-07-09 公開日 2009-07-21 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Free and ATP-bound structures of Ap(4)A hydrolase from Aquifex aeolicus V5 Acta Crystallogr.,Sect.D, 66, 2010
3I9X	Crystal structure of a mutT/nudix family protein from Listeria innocua 分子名称: GLYCEROL, mutT/nudix family protein 著者 Bonanno, J.B, Gilmore, M, Bain, K.T, Miller, S, Romero, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2009-07-13 公開日 2009-07-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of a mutT/nudix family protein from Listeria innocua To be Published
3I7U	Crystal structure of AP4A hydrolase (aq_158) from Aquifex aeolicus VF5 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AP4A hydrolase, ... 著者 Jeyakanthan, J, Kanaujia, S.P, Nakagawa, N, Sekar, K, Kuramitsu, S, Shinkai, A, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2009-07-09 公開日 2009-07-21 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Free and ATP-bound structures of Ap(4)A hydrolase from Aquifex aeolicus V5 Acta Crystallogr.,Sect.D, 66, 2010
8TF9	Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with myo-5-IP7, produced upon myo-IP6 phosphorylation by TvI 分子名称: (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ... 著者 Zong, G, Wang, H, Shears, S.B. 登録日 2023-07-09 公開日 2023-11-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
8TFA	Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with myo-5-PP-IP4, produced upon myo-(2OH)-IP5 phosphorylation by TvIPK 分子名称: (1r,2R,3S,4r,5R,6S)-4-hydroxy-2,3,5,6-tetrakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ... 著者 Zong, G, Wang, H, Shears, S.B. 登録日 2023-07-09 公開日 2023-11-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. Embo J., 43, 2024
3SHD	Crystal structure of Nudix hydrolase Orf153, ymfB, from Escherichia coli K-1 分子名称: MANGANESE (II) ION, Phosphatase nudJ, SULFATE ION 著者 Hong, M.K, Kim, J.K, Kang, L.W. 登録日 2011-06-16 公開日 2012-06-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure and atypical hydrolysis mechanism of the Nudix hydrolase Orf153 (YmfB) from Escherichia coli To be Published
3SMD	Crystal structure of a mut/nudix family protein from bacillus thuringiensis 分子名称: MutT/NUDIX family protein 著者 Palani, K, Kumaran, D, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2011-06-27 公開日 2011-07-20 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Crystal structure of a mut/nudix family protein from bacillus thuringiensis To be Published
3HYQ	Crystal Structure of Isopentenyl-Diphosphate delta-Isomerase from Salmonella entericase 分子名称: Isopentenyl-diphosphate Delta-isomerase 著者 Kim, Y, Zhou, M, Peterson, S, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2009-06-22 公開日 2009-06-30 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.525 Å) 主引用文献 Crystal Structure of Isopentenyl-Diphosphate delta-Isomerase from Salmonella entericase To be Published
3Q93	Crystal Structure of Human 8-oxo-dGTPase (MTH1) 分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, GLYCEROL, IMIDAZOLE, ... 著者 Tresaugues, L, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Ekblad, T, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Karlberg, T, Kol, S, Kotenyova, T, Kouznetsova, E, Moche, M, Nyman, T, Persson, C, Schuler, H, Schutz, P, Thorsell, A.G, Van Der Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Nordlund, P, Structural Genomics Consortium (SGC) 登録日 2011-01-07 公開日 2011-03-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of Human 8-oxo-dGTPase (MTH1) To be Published
3L85	Crystal structure of human NUDT5 complexed with 8-oxo-dGMP 分子名称: 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, ADP-sugar pyrophosphatase 著者 Arimori, T, Yamagata, Y. 登録日 2009-12-29 公開日 2011-01-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Diverse substrate recognition and hydrolysis mechanisms of human NUDT5 Nucleic Acids Res., 39, 2011
3U53	Crystal structure of human Ap4A hydrolase 分子名称: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical], GLYCEROL, SULFATE ION 著者 Ge, H.H, Teng, M.K. 登録日 2011-10-10 公開日 2012-10-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.705 Å) 主引用文献 Crystal structure of wild-type and mutant human Ap4A hydrolase Biochem.Biophys.Res.Commun., 432, 2013
6NL1	Structure of T. brucei MERS1 protein in its apo form 分子名称: Mitochondrial edited mRNA stability factor 1, SULFATE ION 著者 Schumacher, M.A. 登録日 2019-01-07 公開日 2019-11-06 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.297 Å) 主引用文献 Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs inTrypanosoma brucei. Rna, 26, 2020
6P5R	Structure of T. brucei MERS1-GDP complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, Mitochondrial edited mRNA stability factor 1 著者 Schumacher, M.A. 登録日 2019-05-30 公開日 2019-11-06 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs inTrypanosoma brucei. Rna, 26, 2020
6PCK	Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 1-IP7 分子名称: (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ... 著者 Dollins, D.E, Neubauer, J, Dong, J, York, J.D. 登録日 2019-06-17 公開日 2020-04-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling. Proc.Natl.Acad.Sci.USA, 117, 2020
6PCL	Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 5-IP7 分子名称: (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ... 著者 Dollins, D.E, Neubauer, J, Dong, J, York, J.D. 登録日 2019-06-17 公開日 2020-04-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling. Proc.Natl.Acad.Sci.USA, 117, 2020
6JVF	Crystal structure of human apo MTH1 分子名称: 7,8-dihydro-8-oxoguanine triphosphatase 著者 Peng, C, Cheng, Y.S. 登録日 2019-04-17 公開日 2020-10-28 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity. Bioorg.Chem., 110, 2021
6JVL	Crystal structure of human MTH1 in complex with compound MI1014 分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, N4-cyclopropyl-5-ethyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine 著者 Peng, C, Li, Y.H, Cheng, Y.S. 登録日 2019-04-17 公開日 2020-10-28 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity. Bioorg.Chem., 110, 2021
6AA5	Crystal structure of MTH1 in complex with 3-isomangostin 分子名称: 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, ... 著者 Yokoyama, T, Kitakami, R, Mizuguchi, M. 登録日 2018-07-17 公開日 2019-03-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.901 Å) 主引用文献 Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening. Eur J Med Chem, 167, 2019

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