6PCL

Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 5-IP7

Summary for 6PCL

Entry DOI	10.2210/pdb6pcl/pdb
Descriptor	Diphosphoinositol polyphosphate phosphohydrolase 1, (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	inositol pyrophosphate, inositol phosphate, kinase, phosphatase, ppip5k, cell polarity, osmotic response, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	17999.20
Authors	Dollins, D.E.,Neubauer, J.,Dong, J.,York, J.D. (deposition date: 2019-06-17, release date: 2020-04-29, Last modification date: 2023-10-11)
Primary citation	Dollins, D.E.,Bai, W.,Fridy, P.C.,Otto, J.C.,Neubauer, J.L.,Gattis, S.G.,Mehta, K.P.M.,York, J.D. Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling. Proc.Natl.Acad.Sci.USA, 117:9356-9364, 2020 Cited by PubMed: 32303658 DOI: 10.1073/pnas.1908875117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation