PDB: 616 件ウェブページステータス検索Chemie searchBIRD

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7QI1	Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424 分子名称: 14-3-3 protein theta, ARGININE, Cystic fibrosis transmembrane conductance regulator, ... 著者 Stevers, L.M, Ottmann, C. 登録日 2021-12-14 公開日 2022-05-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR. Nat Commun, 13, 2022
4N84	Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS 分子名称: 14-3-3 protein zeta/delta, Exoenzyme S 著者 Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. 登録日 2013-10-17 公開日 2014-02-19 最終更新日 2014-03-12 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
3LW1	Binary complex of 14-3-3 sigma and p53 pT387-peptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... 著者 Schumacher, B, Mondry, J, Thiel, P, Weyand, M, Ottmann, C. 登録日 2010-02-23 公開日 2010-03-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Structure of the p53 C-terminus bound to 14-3-3: Implications for stabilization of the p53 tetramer Febs Lett., 584, 2010
3M51	Structure of the 14-3-3/PMA2 complex stabilized by Pyrrolidone1 分子名称: 14-3-3-like protein C, 2-hydroxy-5-[(5S)-3-hydroxy-5-(4-nitrophenyl)-2-oxo-4-(phenylcarbonyl)-2,5-dihydro-1H-pyrrol-1-yl]benzoic acid, N.plumbaginifolia H+-translocating ATPase mRNA 著者 Ottmann, C, Rose, R, Waldmann, H. 登録日 2010-03-12 公開日 2010-05-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions Angew.Chem.Int.Ed.Engl., 49, 2010
3M50	Structure of the 14-3-3/PMA2 complex stabilized by Epibestatin 分子名称: 14-3-3-like protein C, N-[(2R,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine, N.plumbaginifolia H+-translocating ATPase mRNA 著者 Ottmann, C, Rose, R, Waldmann, H. 登録日 2010-03-12 公開日 2010-05-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions Angew.Chem.Int.Ed.Engl., 49, 2010
4N7Y	Crystal structure of 14-3-3zeta in complex with a 8-carbon-linker cyclic peptide derived from ExoS 分子名称: 14-3-3 protein zeta/delta, Exoenzyme S 著者 Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. 登録日 2013-10-16 公開日 2014-02-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
4O46	14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228 分子名称: 14-3-3 protein gamma, Nonstructural protein 1, UNKNOWN ATOM OR ION, ... 著者 Qin, S, Liu, Y, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2013-12-18 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1. Nat Commun, 5, 2014
4JDD	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface 分子名称: 14-3-3 protein sigma, Estrogen receptor Peptide, FUSICOCCIN 著者 Bier, D, Ottmann, C. 登録日 2013-02-25 公開日 2013-05-15 最終更新日 2017-06-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
4JC3	14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface 分子名称: 14-3-3 protein sigma, Estrogen receptor Peptide, MAGNESIUM ION 著者 Bier, D, Ottmann, C. 登録日 2013-02-21 公開日 2013-05-15 最終更新日 2017-06-07 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
3MHR	14-3-3 sigma in complex with YAP pS127-peptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Schumacher, B, Skwarczynska, M, Rose, R, Ottmann, C. 登録日 2010-04-08 公開日 2010-09-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Structure of a 14-3-3[sigma]-YAP phosphopeptide complex at 1.15 A resolution Acta Crystallogr.,Sect.F, 66, 2010
4N7G	Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS 分子名称: 14-3-3 protein zeta/delta, Exoenzyme S, HEXAETHYLENE GLYCOL 著者 Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. 登録日 2013-10-15 公開日 2014-02-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
3NKX	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome 分子名称: 14-3-3 protein zeta/delta, PROPANOIC ACID, Peptide of RAF proto-oncogene serine/threonine-protein kinase 著者 Schumacher, B, Weyand, M, Ottmann, C. 登録日 2010-06-21 公開日 2010-09-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling Mol.Cell.Biol., 30, 2010
4QLI	A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation 分子名称: 14-3-3 protein sigma, GLYCEROL, MAGNESIUM ION, ... 著者 Bier, D, Ottmann, C. 登録日 2014-06-12 公開日 2015-06-17 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation To be Published
4Y3B	Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma 分子名称: (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-THR-[H][C@@]1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCCN1C 著者 Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C. 登録日 2015-02-10 公開日 2015-12-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
4Y32	Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma 分子名称: (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-CNC(C(C)O)C(=O)N1CCCC1CCOC 著者 Bartel, M, Milroy, L, Bier, D, Brunsveld, L, Ottmann, C. 登録日 2015-02-10 公開日 2015-12-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. 分子名称: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-12 公開日 2023-10-25 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTC	Crystal structure of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. 分子名称: 14-3-3-like protein GF14 omega, COBALT (II) ION, Protein BRASSINAZOLE-RESISTANT 1, ... 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-12 公開日 2023-11-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTT	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the inhibitor protein BKI1. 分子名称: 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, BRI1 kinase inhibitor 1, ... 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-13 公開日 2023-11-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTF	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, ... 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-12 公開日 2023-11-22 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
4ZQ0	crystal structure of Giardia 14-3-3 in complex with the phosphopeptide A8Ap 分子名称: 14-3-3 protein, A8Ap phosphopeptide, PHOSPHATE ION 著者 Fiorillo, A, Ilari, A. 登録日 2015-05-08 公開日 2016-03-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
4Y5I	Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Microtubule-associated protein tau 著者 Leysen, S, Bartel, M, Milroy, L, Brunsveld, L, Ottmann, C. 登録日 2015-02-11 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
4ZDR	Crystal structure of 14-3-3[zeta]-LKB1 fusion protein 分子名称: 14-3-3 protein zeta/delta,GGSGGS linker,Serine/threonine-protein kinase STK11, GLYCEROL, PROPANE, ... 著者 Ding, S, Shi, Z.B. 登録日 2015-04-18 公開日 2015-09-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.899 Å) 主引用文献 Structure of the 14-3-3 zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3. Acta Crystallogr.,Sect.F, 71, 2015
8Q1S	Pathogenic mutations of human phosphorylation sites affect protein-protein interactions 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein epsilon, BROMIDE ION, ... 著者 Roske, Y, Daumke, O, Rrustemi, T, Selbach, M. 登録日 2023-08-01 公開日 2024-02-21 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (3.23 Å) 主引用文献 Pathogenic mutations of human phosphorylation sites affect protein-protein interactions. Nat Commun, 15, 2024
5BTV	Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Ottmann, C, Schumacher, B, Bartel, M. 登録日 2015-06-03 公開日 2016-07-20 最終更新日 2019-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. Faseb J., 29, 2015
5BY9	The crystal structure of polyglycilated 14-3-3 protein from Giardia intestinalis 分子名称: 14-3-3 protein 著者 Fiorillo, A, Ilari, A, Lalle, M. 登録日 2015-06-10 公開日 2016-04-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015

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