3L5N
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6YO6
| Structure of iC3b1 | 分子名称: | hC3Nb1, iC3b1 alpha chain, iC3b1 beta chain | 著者 | Jensen, R.K, Andersen, G.R. | 登録日 | 2020-04-14 | 公開日 | 2021-02-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (6 Å) | 主引用文献 | Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b. J Immunol., 206, 2021
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6YSQ
| The hC4Nb8 complement inhibitory nanobody in complex with C4b | 分子名称: | Complement C4 beta chain, Complement C4 gamma chain, Complement C4-A alpha chain, ... | 著者 | Zarantonello, A, Laursen, N.S, Andersen, G.R. | 登録日 | 2020-04-23 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase. J Immunol., 205, 2020
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7AD6
| Crystal structure of human complement C5 in complex with the K92 bovine knob domain peptide. | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CYSTEINE, ... | 著者 | Macpherson, A, van den Elsen, J.M.H, Schulze, M.E, Birtley, J.R. | 登録日 | 2020-09-14 | 公開日 | 2021-03-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | The allosteric modulation of Complement C5 by knob domain peptides. Elife, 10, 2021
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7AD7
| Crystal structure of human complement C5 in complex with the K8 bovine knob domain peptide. | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Macpherson, A, van den Elsen, J.M.H, Schulze, M.E, Birtley, J.R. | 登録日 | 2020-09-14 | 公開日 | 2021-03-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The allosteric modulation of Complement C5 by knob domain peptides. Elife, 10, 2021
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7B2M
| Cryo-EM structure of complement C4b in complex with nanobody E3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-C4b nanobody E3, Complement C4 alpha chain, ... | 著者 | Oosterheert, W, De la O Becerra, K.I, van den Bos, R.M, Gros, P. | 登録日 | 2020-11-27 | 公開日 | 2022-03-02 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Multifaceted Activities of Seven Nanobodies against Complement C4b. J Immunol., 208, 2022
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7B2Q
| Cryo-EM structure of complement C4b in complex with nanobody B12 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-C4b nanobody B12, ... | 著者 | Oosterheert, W, De la O Becerra, K.I, Gros, P. | 登録日 | 2020-11-27 | 公開日 | 2022-03-02 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | 主引用文献 | Multifaceted Activities of Seven Nanobodies against Complement C4b. J Immunol., 208, 2022
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7B2P
| Cryo-EM structure of complement C4b in complex with nanobody B5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C4 alpha chain, ... | 著者 | Oosterheert, W, De la O Becerra, K.I, Gros, P. | 登録日 | 2020-11-27 | 公開日 | 2022-03-02 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Multifaceted Activities of Seven Nanobodies against Complement C4b. J Immunol., 208, 2022
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5FO7
| Crystal Structure of Human Complement C3b at 2.8 Angstrom resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN | 著者 | Forneris, F, Wu, J, Xue, X, Gros, P. | 登録日 | 2015-11-18 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
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5HCC
| Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Dermacentor andersoni RaCI3. | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jore, M.M, Johnson, S, Lea, S.M. | 登録日 | 2016-01-04 | 公開日 | 2016-03-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Structural basis for therapeutic inhibition of complement C5. Nat.Struct.Mol.Biol., 23, 2016
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5HCD
| Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus microplus RaCI2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ... | 著者 | Jore, M.M, Johnson, S, Lea, S.M. | 登録日 | 2016-01-04 | 公開日 | 2016-03-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Structural basis for therapeutic inhibition of complement C5. Nat.Struct.Mol.Biol., 23, 2016
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5HCE
| Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus appendiculatus RaCI1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ... | 著者 | Jore, M.M, Johnson, S, Lea, S.M. | 登録日 | 2016-01-04 | 公開日 | 2016-03-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | Structural basis for therapeutic inhibition of complement C5. Nat.Struct.Mol.Biol., 23, 2016
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5I5K
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7O7Q
| (h-alpha2M)4 trypsin-activated state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | 登録日 | 2021-04-13 | 公開日 | 2022-04-13 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7O7M
| (h-alpha2M)4 native II | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | 登録日 | 2021-04-13 | 公開日 | 2022-04-13 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | 主引用文献 | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7O7O
| (h-alpha2M)4 semiactivated II state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | 登録日 | 2021-04-13 | 公開日 | 2022-04-13 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7O7N
| (h-alpha2M)4 semiactivated I state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin | 著者 | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | 登録日 | 2021-04-13 | 公開日 | 2022-04-13 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (7.3 Å) | 主引用文献 | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7O7R
| (h-alpha2M)4 plasmin-activated I state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | 登録日 | 2021-04-13 | 公開日 | 2022-04-13 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7O7P
| (h-alpha2M)4 activated state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin | 著者 | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | 登録日 | 2021-04-13 | 公開日 | 2022-04-13 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7O7L
| (h-alpha2M)4 native I | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | 登録日 | 2021-04-13 | 公開日 | 2022-04-20 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7O7S
| (h-alpha2M)4 plasmin-activated II state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | 登録日 | 2021-04-13 | 公開日 | 2022-04-13 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7OP0
| Crystal structure of complement C5 in complex with chemically synthesized K92 knob domain. | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, ... | 著者 | Macpherson, A, van der Elsen, J.M.H, Schulze, M.E, Birtley, J.R. | 登録日 | 2021-05-28 | 公開日 | 2022-04-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | The Chemical Synthesis of Knob Domain Antibody Fragments. Acs Chem.Biol., 16, 2021
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7Q61
| Structure of TEV conjugated A2ML1 (A2ML1-TC) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1 | 著者 | Nielsen, N.S, Zarantonello, A, Andersen, G.R. | 登録日 | 2021-11-05 | 公開日 | 2022-04-20 | 最終更新日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. Nat Commun, 13, 2022
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7Q1Y
| X-ray structure of human A2ML1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1, ... | 著者 | Andersen, G.R, Zarantonello, A, Enghild, J.J, Nielsen, N.S. | 登録日 | 2021-10-22 | 公開日 | 2022-04-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. Nat Commun, 13, 2022
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7Q62
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