8DWM
| Host-guest complex of bleomycin A2 fully bound to CTTAGTTATAACTAAG | 分子名称: | BLEOMYCIN A2, COBALT (III) ION, DNA (5'-D(*CP*TP*TP*AP*GP*TP*TP*A)-3'), ... | 著者 | Georgiadis, M.M. | 登録日 | 2022-08-01 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A 2 and B 2 bound to duplex 5'-TAGTT sites. Bioorg.Med.Chem., 77, 2023
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8DW1
| Crystal structure of a host-guest complex with 5'-CTTAGTTATAACTAAG-3' | 分子名称: | DNA (5'-D(*CP*TP*TP*AP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*TP*AP*AP*G)-3'), reverse transcriptase | 著者 | Georgiadis, M.M. | 登録日 | 2022-07-30 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.849 Å) | 主引用文献 | Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A 2 and B 2 bound to duplex 5'-TAGTT sites. Bioorg.Med.Chem., 77, 2023
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8DW8
| Host-guest structure of BLMA2 partially bound to 5'-ATTAGTTATAACTAAT-3' | 分子名称: | BLEOMYCIN A2, DNA (5'-D(*AP*TP*TP*AP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*TP*AP*AP*T)-3'), ... | 著者 | Georgiadis, M.M. | 登録日 | 2022-07-31 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A 2 and B 2 bound to duplex 5'-TAGTT sites. Bioorg.Med.Chem., 77, 2023
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8C8J
| Long Interspersed Nuclear Element 1 (LINE-1) reverse transcriptase ternary complex with hybrid duplex and dTTP | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, CHLORIDE ION, ... | 著者 | Nichols, C.E, Walpole, T.B, Baldwin, E. | 登録日 | 2023-01-20 | 公開日 | 2023-12-20 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structures, functions and adaptations of the human LINE-1 ORF2 protein. Nature, 626, 2024
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3FSI
| Crystal structure of a trypanocidal 4,4'-Bis(imidazolinylamino)diphenylamine bound to DNA | 分子名称: | 5'-D(*CP*TP*TP*AP*AP*TP*TP*C)-3', 5'-D(P*GP*AP*AP*TP*TP*AP*AP*G)-3', ACETATE ION, ... | 著者 | Glass, L.S, Georgiadis, M.M, Goodwin, K.D. | 登録日 | 2009-01-09 | 公開日 | 2009-05-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structure of a trypanocidal 4,4'-bis(imidazolinylamino)diphenylamine bound to DNA. Biochemistry, 48, 2009
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5VBS
| Structural basis for a six letter alphabet including GATCKX | 分子名称: | DNA (5'-D(*CP*TP*TP*AP*TP*(DX)P*(DX)P*T)-3'), DNA (5'-D(P*AP*(93D)P*(93D)P*AP*TP*AP*AP*G)-3'), reverse transcriptase catalytic fragment | 著者 | Singh, I, Georgiadis, M.M. | 登録日 | 2017-03-30 | 公開日 | 2018-03-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.749 Å) | 主引用文献 | Structure and Biophysics for a Six Letter DNA Alphabet that Includes Imidazo[1,2-a]-1,3,5-triazine-2(8H)-4(3H)-dione (X) and 2,4-Diaminopyrimidine (K). ACS Synth Biol, 6, 2017
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1I6J
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6B1Q
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6B1S
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6B1R
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8UW3
| Human LINE-1 retrotransposon ORF2 protein engaged with template RNA in elongation state | 分子名称: | Complementary DNA, LINE-1 retrotransposable element ORF2 protein, THYMIDINE-5'-TRIPHOSPHATE, ... | 著者 | Thawani, A, Florez Ariza, A.J, Collins, K, Nogales, E. | 登録日 | 2023-11-06 | 公開日 | 2023-12-20 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Template and target-site recognition by human LINE-1 in retrotransposition. Nature, 626, 2024
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6ME0
| Structure of a group II intron retroelement prior to DNA integration | 分子名称: | MAGNESIUM ION, Maturase reverse transcriptase, SODIUM ION, ... | 著者 | Haack, D, Yan, X, Zhang, C, Hingey, J, Lyumkis, D, Baker, T.S, Toor, N. | 登録日 | 2018-09-05 | 公開日 | 2019-08-14 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA. Cell, 178, 2019
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6E53
| Structure of TERT in complex with a novel telomerase inhibitor | 分子名称: | MAGNESIUM ION, RNA/DNA hairpin, Telomerase reverse transcriptase, ... | 著者 | Hernandez-Sanchez, W, Huang, W, Plucinsky, B, Garcia-Vazquez, N, Berdis, A.J, Skordalakes, E, Taylor, D.J. | 登録日 | 2018-07-19 | 公開日 | 2019-03-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity. Plos Biol., 17, 2019
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6MEC
| Structure of a group II intron retroelement after DNA integration | 分子名称: | MAGNESIUM ION, Maturase reverse transcriptase, SODIUM ION, ... | 著者 | Haack, D, Yan, X, Zhang, C, Hingey, J, Lyumkis, D, Baker, T.S, Toor, N. | 登録日 | 2018-09-06 | 公開日 | 2019-08-14 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA. Cell, 178, 2019
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7BG9
| The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate | 分子名称: | DNA (5'-D(P*TP*TP*AP*GP*GP*G)-3'), Histone H2A, Histone H2B, ... | 著者 | Nguyen, T.H.D, Ghanim, G.E, Fountain, A.J, van Roon, A.M.M, Rangan, R, Das, R, Collins, K. | 登録日 | 2021-01-06 | 公開日 | 2021-04-28 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of human telomerase holoenzyme with bound telomeric DNA. Nature, 593, 2021
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7D0F
| cryo-EM structure of a pre-catalytic group II intron RNP | 分子名称: | Group II intron-encoded protein LtrA, RNA (738-MER) | 著者 | Liu, N, Dong, X.L, Hu, C.X, Zeng, J.W, Wang, J.W, Wang, J, Wang, H.W, Belfort, M. | 登録日 | 2020-09-10 | 公開日 | 2020-09-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (5 Å) | 主引用文献 | Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing. Nucleic Acids Res., 48, 2020
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7D0G
| Cryo-EM structure of a pre-catalytic group II intron | 分子名称: | Group II intron-encoded protein LtrA, RNA (714-MER) | 著者 | Liu, N, Dong, X.L, Hu, C.X, Zeng, J.W, Wang, J.W, Wang, J, Wang, H.W, Belfort, M. | 登録日 | 2020-09-10 | 公開日 | 2020-09-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (5 Å) | 主引用文献 | Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing. Nucleic Acids Res., 48, 2020
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7D1A
| cryo-EM structure of a group II intron RNP complexed with its reverse transcriptase | 分子名称: | Group II intron-encoded protein LtrA, RNA (5'-R(P*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*C)-3'), RNA (692-MER) | 著者 | Liu, N, Dong, X.L, Hu, C.X, Zeng, J.W, Wang, J.W, Wang, J, Wang, H.W, Belfort, M. | 登録日 | 2020-09-14 | 公開日 | 2020-10-21 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing. Nucleic Acids Res., 48, 2020
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7QXA
| Cryo-EM map of human telomerase-DNA-TPP1 complex (sharpened) | 分子名称: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | 著者 | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | 登録日 | 2022-01-26 | 公開日 | 2022-03-02 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis of human telomerase recruitment by TPP1-POT1. Science, 375, 2022
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7QXS
| Cryo-EM structure of human telomerase-DNA-TPP1-POT1 complex (with POT1 side chains) | 分子名称: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | 著者 | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | 登録日 | 2022-01-27 | 公開日 | 2022-03-02 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | 主引用文献 | Structural basis of human telomerase recruitment by TPP1-POT1. Science, 375, 2022
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7QXB
| Cryo-EM map of human telomerase-DNA-TPP1-POT1 complex (sharpened map) | 分子名称: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | 著者 | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | 登録日 | 2022-01-26 | 公開日 | 2022-03-02 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | 主引用文献 | Structural basis of human telomerase recruitment by TPP1-POT1. Science, 375, 2022
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7V99
| catalytic core of human telomerase holoenzyme | 分子名称: | Histone H2A type 1-B/E, Histone H2B type 1-K, Primer DNA, ... | 著者 | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | 登録日 | 2021-08-24 | 公開日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Zipper head mechanism of telomere synthesis by human telomerase. Cell Res., 31, 2021
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6ZDU
| Structure of telomerase from Candida albicans in complexe with TWJ fragment of telomeric RNA | 分子名称: | Chains: C,D, Telomerase reverse transcriptase | 著者 | Zhai, L, Rety, S, Chen, W.F, Auguin, D, Xi, X.G. | 登録日 | 2020-06-15 | 公開日 | 2021-04-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi‡. Nucleic Acids Res., 49, 2021
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6ZDQ
| Structure of telomerase from Candida albicans in complexe with TWJ fragment of telomeric RNA | 分子名称: | RNA, Telomerase reverse transcriptase | 著者 | Zhai, L, Rety, S, Chen, W.F, Auguin, D, Xi, X.G. | 登録日 | 2020-06-15 | 公開日 | 2021-04-28 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi‡. Nucleic Acids Res., 49, 2021
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3KYL
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