7U4E
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7U4F
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7U4G
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5JYY
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![BU of 5jyy by Molmil](/molmil-images/mine/5jyy) | Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-[(2-methoxyethyl)carbamoyl]-D-glycero-D-galacto-non-2-enon ic acid, CALCIUM ION, ... | 著者 | Fu, L, Wu, Y, Bi, Y, Zhang, S, Lv, X, Qi, J, Li, Y, Lu, X, Yan, J, Gao, G.F, Li, X. | 登録日 | 2016-05-15 | 公開日 | 2016-06-29 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses J.Med.Chem., 59, 2016
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5NWE
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![BU of 5nwe by Molmil](/molmil-images/mine/5nwe) | Complex of H275Y mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Pachl, P, Pokorna, J. | 登録日 | 2017-05-05 | 公開日 | 2018-07-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus. Viruses, 10, 2018
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5NZ4
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![BU of 5nz4 by Molmil](/molmil-images/mine/5nz4) | Complex of I223V mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Pachl, P, Pokorna, J, Karlukova, E. | 登録日 | 2017-05-12 | 公開日 | 2018-07-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus. Viruses, 10, 2018
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3K3A
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5NZF
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![BU of 5nzf by Molmil](/molmil-images/mine/5nzf) | Complex of H275Y/I223V mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Pachl, P, Pokorna, J. | 登録日 | 2017-05-14 | 公開日 | 2018-07-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus. Viruses, 10, 2018
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5NZN
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![BU of 5nzn by Molmil](/molmil-images/mine/5nzn) | Complex of H275Y/S247N mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Pachl, P, Pokorna, J. | 登録日 | 2017-05-14 | 公開日 | 2018-07-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus. Viruses, 10, 2018
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5L17
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5L15
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![BU of 5l15 by Molmil](/molmil-images/mine/5l15) | The crystal structure of neuraminidase in complex with oseltamivir from A/Shanghai/2/2013 (H7N9) influenza virus | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Yang, H, Stevens, J. | 登録日 | 2016-07-28 | 公開日 | 2017-08-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Drug Susceptibility Evaluation of an Influenza A(H7N9) Virus by Analyzing Recombinant Neuraminidase Proteins. J. Infect. Dis., 216, 2017
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5L18
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7E6Q
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![BU of 7e6q by Molmil](/molmil-images/mine/7e6q) | Crystal structure of influenza A virus neuraminidase N5 complexed with 4'-phenyl-1,2,3-triazolylated oseltamivir carboxylate | 分子名称: | (3R,4R,5S)-4-acetamido-3-pentan-3-yloxy-5-(4-phenyl-1,2,3-triazol-1-yl)cyclohexene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Wang, P.F, Babayemi, O.O, Li, C.N, Fu, L.F, Zhang, S.S, Qi, J.X, Lv, X, Li, X.B. | 登録日 | 2021-02-23 | 公開日 | 2021-03-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-based design of 5'-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors. Rsc Adv, 11, 2021
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5L14
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7FGD
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![BU of 7fgd by Molmil](/molmil-images/mine/7fgd) | A naturally-occurring neuraminidase-inhibitors-resistant NA from asiatic toad influenza B-like virus | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, toad NA (OSE) | 著者 | Chai, Y, Wu, Y, Gao, F. | 登録日 | 2021-07-26 | 公開日 | 2022-08-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel. Proc.Natl.Acad.Sci.USA, 119, 2022
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7FGC
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7FGB
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![BU of 7fgb by Molmil](/molmil-images/mine/7fgb) | A naturally-occurring neuraminidase-inhibitors-resistant NA from asiatic toad influenza B-like virus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, SULFATE ION, ... | 著者 | Chai, Y, Wu, Y, Gao, F. | 登録日 | 2021-07-26 | 公開日 | 2022-08-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel. Proc.Natl.Acad.Sci.USA, 119, 2022
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1B9T
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![BU of 1b9t by Molmil](/molmil-images/mine/1b9t) | NOVEL AROMATIC INHIBITORS OF INFLUENZA VIRUS NEURAMINIDASE MAKE SELECTIVE INTERACTIONS WITH CONSERVED RESIDUES AND WATER MOLECULES IN THE ACTIVE SITE | 分子名称: | 1-(4-CARBOXY-2-GUANIDINOPENTYL)-5,5'-DI(HYDROXYMETHYL)PYRROLIDIN-2-ONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Finley, J.B, Atigadda, V.R, Duarte, F, Zhao, J.J, Brouillette, W.J, Air, G.M, Luo, M. | 登録日 | 1999-02-15 | 公開日 | 1999-02-27 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Novel aromatic inhibitors of influenza virus neuraminidase make selective interactions with conserved residues and water molecules in the active site. J.Mol.Biol., 293, 1999
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4QN7
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![BU of 4qn7 by Molmil](/molmil-images/mine/4qn7) | Crystal structure of neuramnidase N7 complexed with Oseltamivir | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Sun, X, Li, Q, Wu, Y, Liu, Y, Qi, J, Vavricka, C.J, Gao, G.F. | 登録日 | 2014-06-17 | 公開日 | 2014-07-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | 主引用文献 | Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle. J.Virol., 88, 2014
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4QN4
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![BU of 4qn4 by Molmil](/molmil-images/mine/4qn4) | Crystal structure of Neuraminidase N6 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, GLYCEROL, ... | 著者 | Sun, X, Li, Q, Wu, Y, Liu, Y, Qi, J, Vavricka, C.J, Gao, G.F. | 登録日 | 2014-06-17 | 公開日 | 2014-07-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle. J.Virol., 88, 2014
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4QN5
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![BU of 4qn5 by Molmil](/molmil-images/mine/4qn5) | Neuraminidase N5 binds LSTa at the second SIA binding site | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Sun, X, Li, Q, Wu, Y, Liu, Y, Qi, J, Vavricka, C.J, Gao, G.F. | 登録日 | 2014-06-17 | 公開日 | 2014-07-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle. J.Virol., 88, 2014
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4QN6
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![BU of 4qn6 by Molmil](/molmil-images/mine/4qn6) | Crystal structure of Neuraminidase N6 complexed with Laninamivir | 分子名称: | 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, CALCIUM ION, Neuraminidase, ... | 著者 | Sun, X, Li, Q, Wu, Y, Liu, Y, Qi, J, Vavricka, C.J, Gao, G.F. | 登録日 | 2014-06-17 | 公開日 | 2014-07-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.945 Å) | 主引用文献 | Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle. J.Virol., 88, 2014
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4QN3
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![BU of 4qn3 by Molmil](/molmil-images/mine/4qn3) | Crystal structure of Neuraminidase N7 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Sun, X, Li, Q, Wu, Y, Liu, Y, Qi, J, Vavricka, C.J, Gao, G.F. | 登録日 | 2014-06-17 | 公開日 | 2014-07-30 | 最終更新日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | 主引用文献 | Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle. J.Virol., 88, 2014
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3CKZ
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![BU of 3ckz by Molmil](/molmil-images/mine/3ckz) | N1 Neuraminidase H274Y + Zanamivir | 分子名称: | CALCIUM ION, Neuraminidase, ZANAMIVIR | 著者 | Colllins, P, Haire, L.F, Lin, Y.P, Liu, J, Russell, R.J, Walker, P.A, Skehel, J.J, Martin, S.R, Hay, A.J, Gamblin, S.J. | 登録日 | 2008-03-18 | 公開日 | 2008-05-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature, 453, 2008
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6MCX
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![BU of 6mcx by Molmil](/molmil-images/mine/6mcx) | INFLUENZA VIRUS NEURAMINIDASE SUBTYPE N9 (TERN) RECOMBINANT HEAD DOMAIN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | 著者 | Streltsov, V.A, Schmidt, P, McKimm-Breschkin, J. | 登録日 | 2018-09-02 | 公開日 | 2019-01-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of an Influenza A virus N9 neuraminidase with a tetrabrachion-domain stalk. Acta Crystallogr.,Sect.F, 75, 2019
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