5NZ4

Complex of I223V mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir

Summary for 5NZ4

Entry DOI	10.2210/pdb5nz4/pdb
Related	5NWE 5NZE 5NZF 5NZN
Descriptor	neuraminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	neuraminidase, influenza, complex, inhibitor, hydrolase
Biological source	unidentified influenza virus
Total number of polymer chains	2
Total formula weight	89078.08
Authors	Pachl, P.,Pokorna, J.,Karlukova, E. (deposition date: 2017-05-12, release date: 2018-07-04, Last modification date: 2024-01-17)
Primary citation	Pokorna, J.,Pachl, P.,Karlukova, E.,Hejdanek, J.,Rezacova, P.,Machara, A.,Hudlicky, J.,Konvalinka, J.,Kozisek, M. Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus. Viruses, 10:-, 2018 Cited by PubMed: 29933553 DOI: 10.3390/v10070339 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.36 Å)

Structure validation