5NZ4

Complex of I223V mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	neuraminidase	polymer	388	42713.6	2	UniProt (C6KQL9) UniProt (by SIFTS) (C3W6G3)	unidentified influenza virus
2	C, D (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	E (E)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
4	F, G, Q, R, V (A, B)	CALCIUM ION	non-polymer		40.1	5	Chemie (CA) PubChem (271)
5	H, S (A, B)	(3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid	non-polymer		284.4	2	Chemie (G39) PubChem (449381) PubChem (4631786) PubChem (40640967) PubChem (40640969) PubChem (40640971) PubChem (44345914) PubChem (40640973) PubChem (58753598) PubChem (71038155) PubChem (71065667) PubChem (95162772) PubChem (121452907) PubChem (124637832) PubChem (129886749) PubChem (134694948) PubChem (137378365)
6	I, T, U (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
7	J, K, L, M, N... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	10	Chemie (EDO)
8	AA, Z (B, A)	water	water		18.0	1072	Chemie (HOH)

Sequence modifications

A, B: 82 - 469 (UniProt: C6KQL9)

PDB	External Database	Details
Val 223	Ile 213	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85427.2
Branched	Number of molecules	3
	Total formula weight	1597.5
Non-Polymers*	Number of molecules	20
	Total formula weight	2053.4
All*	Total formula weight	89078.1

*Water molecules are not included.