5JYY

Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses

Replaces:  5E6L

Summary for 5JYY

Related4MWX
DescriptorNeuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ... (7 entities in total)
Functional Keywordsneuraminidase inhibitor, tetravalent zanamivir, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceInfluenza A virus
Total number of polymer chains1
Total molecular weight46144.92
Authors
Fu, L.,Wu, Y.,Bi, Y.,Zhang, S.,Lv, X.,Qi, J.,Li, Y.,Lu, X.,Yan, J.,Gao, G.F.,Li, X. (deposition date: 2016-05-15, release date: 2016-06-29, Last modification date: 2018-10-24)
Primary citation
Fu, L.,Bi, Y.,Wu, Y.,Zhang, S.,Qi, J.,Li, Y.,Lu, X.,Zhang, Z.,Lv, X.,Yan, J.,Gao, G.F.,Li, X.
Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses
J.Med.Chem., 59:6303-6312, 2016
PubMed: 27341624 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.6b00537
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.17220 0.3% 0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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Molmil generated image of 5jyy
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5jyy.pdb1.gz [574.47 KB])