7E6Q

Crystal structure of influenza A virus neuraminidase N5 complexed with 4'-phenyl-1,2,3-triazolylated oseltamivir carboxylate

Summary for 7E6Q

• Entry DOI: 10.2210/pdb7e6q/pdb
• Descriptor: Neuraminidase, CALCIUM ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: influenza virus, neuraminidase inhibitors, oseltamivir derivatives, 150-cavity, hydrolase
• Biological source: Influenza A virus (strain A/Duck/Alberta/60/1976 H12N5)
• Total number of polymer chains: 2
• Total formula weight: 88632.61

Authors

Wang, P.F.,Babayemi, O.O.,Li, C.N.,Fu, L.F.,Zhang, S.S.,Qi, J.X.,Lv, X.,Li, X.B. (deposition date: 2021-02-23, release date: 2021-03-17, Last modification date: 2023-11-29)

• Primary citation: Wang, P.,Oladejo, B.O.,Li, C.,Fu, L.,Zhang, S.,Qi, J.,Lv, X.,Li, X.; Structure-based design of 5'-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors.; Rsc Adv, 11:9528-9541, 2021; PubMed: 35423449; DOI: 10.1039/d1ra00472g

Experimental method

X-RAY DIFFRACTION (2.2 Å)