PDB: 148 件ウェブページステータス検索Chemie searchBIRD

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5NXE	Crystal structure of TNKS2 in complex with 2-{4-[(2-hydroxyethyl)(methyl)amino]phenyl}-1,2,3,4-tetrahydroquinazolin-4-one 分子名称: 2-[4-[2-hydroxyethyl(methyl)amino]phenyl]-2,3-dihydro-1~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-10 公開日 2018-03-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NWB	Crystal structure of TNKS2 in complex with 2-{4-[(2-hydroxyethyl)(methyl)amino]phenyl}-3,4-dihydroquinazolin-4-one 分子名称: 2-[4-[2-hydroxyethyl(methyl)amino]phenyl]-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-05 公開日 2018-05-02 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NWC	Crystal structure of TNKS2 in complex with 2-(2-aminophenyl)-3,4-dihydroquinazolin-4-one 分子名称: 2-(2-aminophenyl)-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-05 公開日 2018-05-02 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NUT	Crystal structure of TNKS2 in complex with 2-[4-(propan-2-yloxy)phenyl]-3,4-dihydroquinazolin-4-one 分子名称: 2-(4-propan-2-yloxyphenyl)-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-02 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NWG	Crystal structure of TNKS2 in complex with 7-chloro-2-{4-[(2-hydroxyethyl)(methyl)amino]phenyl}-3,4-dihydroquinazolin-4-one 分子名称: 7-chloranyl-2-[4-[2-hydroxyethyl(methyl)amino]phenyl]-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-05 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NVF	Crystal structure of TNKS2 in complex with 2-[4-(pyridin-2-yl)phenyl]-3,4-dihydroquinazolin-4-one 分子名称: 2-(4-pyridin-2-ylphenyl)-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-04 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5OWS	Crystal structure of TNKS2 in complex with 2-[4-(4-methyl-2-oxoimidazolidin-4-yl)phenyl]-3,4-dihydroquinazolin-4-one 分子名称: 2-[4-[(4~{S})-4-methyl-2-oxidanylidene-imidazolidin-4-yl]phenyl]-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-09-04 公開日 2018-05-02 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NVH	Crystal structure of TNKS2 in complex with 2-[4-(piperidin-1-yl)phenyl]-3,4-dihydroquinazolin-4-one 分子名称: 2-(4-piperidin-1-ylphenyl)-3~{H}-quinazolin-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-04 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NSX	Crystal structure of TNKS2 in complex with 2-(1H-indazol-5-yl)-3,4-dihydroquinazolin-4-one 分子名称: 2-(2~{H}-indazol-5-yl)-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-04-27 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NT4	Crystal structure of TNKS2 in complex with 2-[4-(morpholin-4-yl)phenyl]-3,4-dihydroquinazolin-4-one 分子名称: 2-[4-morpholin-4-yl]-3,4-dihydroquinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-04-27 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5OWT	Crystal structure of TNKS2 in complex with (5S)-5-methyl-5-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]imidazolidine-2,4-dione 分子名称: (5S)-5-methyl-5-[4-(4-oxidanylidene-3H-quinazolin-2-yl)phenyl]imidazolidine-2,4-dione, SULFATE ION, Tankyrase-2, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-09-04 公開日 2018-05-02 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NVC	Crystal structure of TNKS2 in complex with 2-(3-hydroxyphenyl)-3,4-dihydroquinazolin-4-one 分子名称: 2-(3-hydroxyphenyl)-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-04 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
5NWD	Crystal structure of TNKS2 in complex with 2-[4-(diethylamino)phenyl]-3,4-dihydroquinazolin-4-one 分子名称: 2-[4-(diethylamino)phenyl]-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ... 著者 Nkizinkiko, Y, Haikarainen, T, Lehtio, L. 登録日 2017-05-05 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8, 2018
2PK2	Cyclin box structure of the P-TEFb subunit Cyclin T1 derived from a fusion complex with EIAV Tat 分子名称: Cyclin-T1, Protein Tat 著者 Anand, K, Schulte, A, Fujinaga, K, Scheffzek, K, Geyer, M. 登録日 2007-04-17 公開日 2007-07-03 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Cyclin Box Structure of the P-TEFb Subunit Cyclin T1 Derived from a Fusion Complex with EIAV Tat. J.Mol.Biol., 370, 2007
2CLX	4-Arylazo-3,5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects 分子名称: 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, CELL DIVISION PROTEIN KINASE 2 著者 Krystof, V, Cankar, P, Frysova, I, Slouka, J, Kontopidis, G, Dzubak, P, Hajduch, M, Deazevedo, W.F, Paprskarova, M, Orsag, M, Rolcik, J, Latr, A, Fischer, P.M, Strnad, M. 登録日 2006-05-02 公開日 2006-11-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 4-Arylazo-3,5-Diamino-1H-Pyrazole Cdk Inhibitors: Sar Study, Crystal Structure in Complex with Cdk2, Selectivity, and Cellular Effects J.Med.Chem., 49, 2006
4NST	Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ... 著者 Boesken, C.A, Farnung, L, Anand, K, Geyer, M. 登録日 2013-11-29 公開日 2014-03-26 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The structure and substrate specificity of human Cdk12/Cyclin K. Nat Commun, 5, 2014
5UY9	Prolyl isomerase Pin1 R14A mutant bound with Brd4 peptide 分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Brd4 peptide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... 著者 Dong, S.-H, Nair, S. 登録日 2017-02-23 公開日 2017-04-26 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4. Oncogene, 36, 2017
3BHV	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B 分子名称: 9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol, Cell division protein kinase 2, Cyclin-A2, ... 著者 Echalier, A, Bettayeb, K, Ferandin, Y, Lozach, O, Clement, M, Valette, A, Liger, F, Marquet, B, Morris, J.C, Endicott, J.A, Joseph, B, Meijer, L. 登録日 2007-11-29 公開日 2008-02-12 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases Cancer Res., 67, 2007
3BHU	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5 分子名称: 4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, Cell division protein kinase 2, Cyclin-A2, ... 著者 Echalier, A, Bettayeb, K, Ferandin, Y, Lozach, O, Clement, M, Valette, A, Liger, F, Marquet, B, Morris, J.C, Endicott, J.A, Joseph, B, Meijer, L. 登録日 2007-11-29 公開日 2008-02-12 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases Cancer Res., 67, 2007
3BHT	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3 分子名称: 4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, Cell division protein kinase 2, Cyclin-A2, ... 著者 Echalier, A, Bettayeb, K, Ferandin, Y, Lozach, O, Clement, M, Valette, A, Liger, F, Marquet, B, Morris, J.C, Endicott, J.A, Joseph, B, Meijer, L. 登録日 2007-11-29 公開日 2008-02-12 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases Cancer Res., 67, 2007
6GZD	Crystal structure of Human CSNK1A1 with A86 分子名称: 1,2-ETHANEDIOL, 3,3',3''-phosphanetriyltripropanoic acid, Casein kinase I isoform alpha, ... 著者 Ben-Neriah, Y, Venkatachalam, A, Minzel, W, Fink, A, Snir-Alkalay, I, Vacca, J. 登録日 2018-07-03 公開日 2018-08-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Small Molecules Co-targeting CKI alpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell, 175, 2018
3JVL	Crystal structure of bromodomain 2 of mouse Brd4 分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Bromodomain-containing protein 4 著者 Vollmuth, F, Blankenfeldt, W, Geyer, M. 登録日 2009-09-17 公開日 2009-10-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution J.Biol.Chem., 284, 2009
3JVK	Crystal structure of bromodomain 1 of mouse Brd4 in complex with histone H3-K(ac)14 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, histone H3.3 peptide 著者 Vollmuth, F, Blankenfeldt, W, Geyer, M. 登録日 2009-09-17 公開日 2009-10-13 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution J.Biol.Chem., 284, 2009
7KJS	Crystal structure of CDK2/cyclin E in complex with PF-06873600 分子名称: 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 著者 McTigue, M.A, He, Y, Ferre, R.A. 登録日 2020-10-26 公開日 2021-06-23 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.187 Å) 主引用文献 Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J.Med.Chem., 64, 2021
3JVJ	Crystal structure of the bromodomain 1 in mouse Brd4 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GLYCEROL 著者 Vollmuth, F, Blankenfeldt, W, Geyer, M. 登録日 2009-09-17 公開日 2009-10-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution J.Biol.Chem., 284, 2009

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