6GZD

Crystal structure of Human CSNK1A1 with A86

Summary for 6GZD

Entry DOI	10.2210/pdb6gzd/pdb
Descriptor	Casein kinase I isoform alpha, DIMETHYL SULFOXIDE, TRIETHYLENE GLYCOL, ... (8 entities in total)
Functional Keywords	ckia, casein kinase, kinase inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	45224.63
Authors	Ben-Neriah, Y.,Venkatachalam, A.,Minzel, W.,Fink, A.,Snir-Alkalay, I.,Vacca, J. (deposition date: 2018-07-03, release date: 2018-08-29, Last modification date: 2024-01-17)
Primary citation	Minzel, W.,Venkatachalam, A.,Fink, A.,Hung, E.,Brachya, G.,Burstain, I.,Shaham, M.,Rivlin, A.,Omer, I.,Zinger, A.,Elias, S.,Winter, E.,Erdman, P.E.,Sullivan, R.W.,Fung, L.,Mercurio, F.,Li, D.,Vacca, J.,Kaushansky, N.,Shlush, L.,Oren, M.,Levine, R.,Pikarsky, E.,Snir-Alkalay, I.,Ben-Neriah, Y. Small Molecules Co-targeting CKI alpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell, 175:171-185.e25, 2018 Cited by PubMed: 30146162 DOI: 10.1016/j.cell.2018.07.045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation