6GZD
Crystal structure of Human CSNK1A1 with A86
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000775 | cellular_component | chromosome, centromeric region |
| A | 0000776 | cellular_component | kinetochore |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005694 | cellular_component | chromosome |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005813 | cellular_component | centrosome |
| A | 0005819 | cellular_component | spindle |
| A | 0005829 | cellular_component | cytosol |
| A | 0005847 | cellular_component | mRNA cleavage and polyadenylation specificity factor complex |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005929 | cellular_component | cilium |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007030 | biological_process | Golgi organization |
| A | 0007165 | biological_process | signal transduction |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0018105 | biological_process | peptidyl-serine phosphorylation |
| A | 0019082 | biological_process | viral protein processing |
| A | 0030877 | cellular_component | beta-catenin destruction complex |
| A | 0031670 | biological_process | cellular response to nutrient |
| A | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| A | 0035025 | biological_process | positive regulation of Rho protein signal transduction |
| A | 0036064 | cellular_component | ciliary basal body |
| A | 0042995 | cellular_component | cell projection |
| A | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| A | 0043227 | cellular_component | membrane-bounded organelle |
| A | 0043229 | cellular_component | intracellular organelle |
| A | 0045095 | cellular_component | keratin filament |
| A | 0045104 | biological_process | intermediate filament cytoskeleton organization |
| A | 0051301 | biological_process | cell division |
| A | 0090090 | biological_process | negative regulation of canonical Wnt signaling pathway |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 1900226 | biological_process | negative regulation of NLRP3 inflammasome complex assembly |
| A | 1904263 | biological_process | positive regulation of TORC1 signaling |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 1001 |
| Chain | Residue |
| A | ARG135 |
| A | LYS179 |
| A | DMS1002 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 1002 |
| Chain | Residue |
| A | ARG135 |
| A | LEU160 |
| A | ALA161 |
| A | DMS1001 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PGE A 1003 |
| Chain | Residue |
| A | SER242 |
| A | THR243 |
| A | HOH1201 |
| A | PRO220 |
| A | LYS239 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue PGE A 1004 |
| Chain | Residue |
| A | GLN119 |
| A | TYR175 |
| A | ASN191 |
| A | ARG201 |
| A | ARG267 |
| A | TYR294 |
| A | HOH1103 |
| A | HOH1142 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue PGE A 1005 |
| Chain | Residue |
| A | ASN261 |
| A | GLN291 |
| A | ASP293 |
| A | HOH1251 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1007 |
| Chain | Residue |
| A | ASP118 |
| A | SER122 |
| A | TYR175 |
| A | HOH1142 |
| A | HOH1175 |
| A | HOH1204 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 1008 |
| Chain | Residue |
| A | TYR59 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1009 |
| Chain | Residue |
| A | ARG170 |
| A | GLN171 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 1011 |
| Chain | Residue |
| A | TYR262 |
| A | ASP273 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 1012 |
| Chain | Residue |
| A | ASP166 |
| A | GLN171 |
| A | HIS172 |
| A | ILE173 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 1013 |
| Chain | Residue |
| A | THR169 |
| A | ARG170 |
| A | MET275 |
| A | GLN279 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 1014 |
| Chain | Residue |
| A | TYR126 |
| A | LYS130 |
| A | ARG176 |
| A | HOH1149 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 1015 |
| Chain | Residue |
| A | PHE11 |
| A | TYR85 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 1016 |
| Chain | Residue |
| A | ASP178 |
| A | LYS179 |
| A | HIS193 |
| A | LEU194 |
| site_id | AD6 |
| Number of Residues | 10 |
| Details | binding site for residue TCE A 1017 |
| Chain | Residue |
| A | THR184 |
| A | ALA185 |
| A | ARG186 |
| A | TRP221 |
| A | GLN222 |
| A | GLY223 |
| A | LEU224 |
| A | LYS232 |
| A | ILE236 |
| A | HOH1156 |
| site_id | AD7 |
| Number of Residues | 10 |
| Details | binding site for residue LCI A 1018 |
| Chain | Residue |
| A | SER25 |
| A | GLY26 |
| A | ILE31 |
| A | ALA44 |
| A | MET90 |
| A | ASP91 |
| A | LEU93 |
| A | GLY94 |
| A | ASP99 |
| A | LEU143 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlAtnitngee..........VAVK |
| Chain | Residue | Details |
| A | ILE23-LYS46 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDIKpdNFLM |
| Chain | Residue | Details |
| A | PHE132-MET144 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP136 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | ILE23 | |
| A | LYS46 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | ALA2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER4 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS8 |
