6GZD

Crystal structure of Human CSNK1A1 with A86

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000776	cellular_component	kinetochore
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005847	cellular_component	mRNA cleavage and polyadenylation specificity factor complex
A	0005929	cellular_component	cilium
A	0006468	biological_process	protein phosphorylation
A	0007030	biological_process	Golgi organization
A	0007165	biological_process	signal transduction
A	0007166	biological_process	cell surface receptor signaling pathway
A	0016020	cellular_component	membrane
A	0016055	biological_process	Wnt signaling pathway
A	0016301	molecular_function	kinase activity
A	0016607	cellular_component	nuclear speck
A	0016740	molecular_function	transferase activity
A	0019082	biological_process	viral protein processing
A	0030111	biological_process	regulation of Wnt signaling pathway
A	0030877	cellular_component	beta-catenin destruction complex
A	0031670	biological_process	cellular response to nutrient
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0035025	biological_process	positive regulation of Rho protein signal transduction
A	0036064	cellular_component	ciliary basal body
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0045095	cellular_component	keratin filament
A	0045104	biological_process	intermediate filament cytoskeleton organization
A	0051301	biological_process	cell division
A	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
A	0106310	molecular_function	protein serine kinase activity
A	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
A	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue DMS A 1001

Chain	Residue
A	ARG135
A	LYS179
A	DMS1002

---

site_id	AC2
Number of Residues	4
Details	binding site for residue DMS A 1002

Chain	Residue
A	ARG135
A	LEU160
A	ALA161
A	DMS1001

---

site_id	AC3
Number of Residues	5
Details	binding site for residue PGE A 1003

Chain	Residue
A	SER242
A	THR243
A	HOH1201
A	PRO220
A	LYS239

---

site_id	AC4
Number of Residues	8
Details	binding site for residue PGE A 1004

Chain	Residue
A	GLN119
A	TYR175
A	ASN191
A	ARG201
A	ARG267
A	TYR294
A	HOH1103
A	HOH1142

---

site_id	AC5
Number of Residues	4
Details	binding site for residue PGE A 1005

Chain	Residue
A	ASN261
A	GLN291
A	ASP293
A	HOH1251

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO A 1007

Chain	Residue
A	ASP118
A	SER122
A	TYR175
A	HOH1142
A	HOH1175
A	HOH1204

---

site_id	AC7
Number of Residues	1
Details	binding site for residue EDO A 1008

Chain	Residue
A	TYR59

---

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO A 1009

Chain	Residue
A	ARG170
A	GLN171

---

site_id	AC9
Number of Residues	2
Details	binding site for residue PEG A 1011

Chain	Residue
A	TYR262
A	ASP273

---

site_id	AD1
Number of Residues	4
Details	binding site for residue PEG A 1012

Chain	Residue
A	ASP166
A	GLN171
A	HIS172
A	ILE173

---

site_id	AD2
Number of Residues	4
Details	binding site for residue PEG A 1013

Chain	Residue
A	THR169
A	ARG170
A	MET275
A	GLN279

---

site_id	AD3
Number of Residues	4
Details	binding site for residue PEG A 1014

Chain	Residue
A	TYR126
A	LYS130
A	ARG176
A	HOH1149

---

site_id	AD4
Number of Residues	2
Details	binding site for residue PEG A 1015

Chain	Residue
A	PHE11
A	TYR85

---

site_id	AD5
Number of Residues	4
Details	binding site for residue PEG A 1016

Chain	Residue
A	ASP178
A	LYS179
A	HIS193
A	LEU194

---

site_id	AD6
Number of Residues	10
Details	binding site for residue TCE A 1017

Chain	Residue
A	THR184
A	ALA185
A	ARG186
A	TRP221
A	GLN222
A	GLY223
A	LEU224
A	LYS232
A	ILE236
A	HOH1156

---

site_id	AD7
Number of Residues	10
Details	binding site for residue LCI A 1018

Chain	Residue
A	SER25
A	GLY26
A	ILE31
A	ALA44
A	MET90
A	ASP91
A	LEU93
A	GLY94
A	ASP99
A	LEU143

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlAtnitngee..........VAVK

Chain	Residue	Details
A	ILE23-LYS46

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDIKpdNFLM

Chain	Residue	Details
A	PHE132-MET144

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	268
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---