5NXE

Crystal structure of TNKS2 in complex with 2-{4-[(2-hydroxyethyl)(methyl)amino]phenyl}-1,2,3,4-tetrahydroquinazolin-4-one

Summary for 5NXE

• Entry DOI: 10.2210/pdb5nxe/pdb
• Descriptor: Tankyrase-2, SULFATE ION, ZINC ION, ... (7 entities in total)
• Functional Keywords: tankyrase, inhibitor, artd6, parp5b, adp-ribosyltransferase, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 55929.48

Authors

Nkizinkiko, Y.,Haikarainen, T.,Lehtio, L. (deposition date: 2017-05-10, release date: 2018-03-21, Last modification date: 2024-01-17)

• Primary citation: Nkizinkiko, Y.,Desantis, J.,Koivunen, J.,Haikarainen, T.,Murthy, S.,Sancineto, L.,Massari, S.,Ianni, F.,Obaji, E.,Loza, M.I.,Pihlajaniemi, T.,Brea, J.,Tabarrini, O.,Lehtio, L.; 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.; Sci Rep, 8:1680-1680, 2018; PubMed: 29374194; DOI: 10.1038/s41598-018-19872-3

Experimental method

X-RAY DIFFRACTION (1.6 Å)