5OWT

Crystal structure of TNKS2 in complex with (5S)-5-methyl-5-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]imidazolidine-2,4-dione

Summary for 5OWT

Entry DOI	10.2210/pdb5owt/pdb
Descriptor	Tankyrase-2, SULFATE ION, (5S)-5-methyl-5-[4-(4-oxidanylidene-3H-quinazolin-2-yl)phenyl]imidazolidine-2,4-dione, ... (5 entities in total)
Functional Keywords	tankyrase, inhibitor, artd6, parp5b, adp-ribosyltransferase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	55783.26
Authors	Nkizinkiko, Y.,Haikarainen, T.,Lehtio, L. (deposition date: 2017-09-04, release date: 2018-05-02, Last modification date: 2024-01-17)
Primary citation	Nkizinkiko, Y.,Desantis, J.,Koivunen, J.,Haikarainen, T.,Murthy, S.,Sancineto, L.,Massari, S.,Ianni, F.,Obaji, E.,Loza, M.I.,Pihlajaniemi, T.,Brea, J.,Tabarrini, O.,Lehtio, L. 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8:1680-1680, 2018 Cited by PubMed: 29374194 DOI: 10.1038/s41598-018-19872-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation