5OWT
Crystal structure of TNKS2 in complex with (5S)-5-methyl-5-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]imidazolidine-2,4-dione
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tankyrase-2 | polymer | 240 | 27299.8 | 2 | UniProt (Q9H2K2) Pfam (PF00644) In PDB | Homo sapiens (Human) | TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein |
2 | A, B | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
3 | A, B | (5S)-5-methyl-5-[4-(4-oxidanylidene-3H-quinazolin-2-yl)phenyl]imidazolidine-2,4-dione | non-polymer | 334.3 | 2 | Chemie (F37) | |||
4 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
5 | water | water | 18.0 | 136 | Chemie (HOH) |
Sequence modifications
A, B: 946 - 1162 (UniProt: Q9H2K2)
PDB | External Database | Details |
---|---|---|
Met 923 | - | initiating methionine |
His 924 | - | expression tag |
His 925 | - | expression tag |
His 926 | - | expression tag |
His 927 | - | expression tag |
His 928 | - | expression tag |
His 929 | - | expression tag |
Ser 930 | - | expression tag |
Ser 931 | - | expression tag |
Gly 932 | - | expression tag |
Val 933 | - | expression tag |
Asp 934 | - | expression tag |
Leu 935 | - | expression tag |
Gly 936 | - | expression tag |
Thr 937 | - | expression tag |
Glu 938 | - | expression tag |
Asn 939 | - | expression tag |
Leu 940 | - | expression tag |
Tyr 941 | - | expression tag |
Phe 942 | - | expression tag |
Gln 943 | - | expression tag |
Ser 944 | - | expression tag |
Met 945 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 54599.5 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1183.7 | |
All* | Total formula weight | 55783.3 |