PDB: 8861 件ウェブページステータス検索Chemie searchBIRD

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8T1J	Uncrosslinked nNOS-CaM oxygenase homodimer 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ARGININE, Nitric oxide synthase 1, ... 著者 Lee, K, Pospiech, T.H, Southworth, D. 登録日 2023-06-02 公開日 2023-11-29 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry. J.Biol.Chem., 300, 2023
8T9U	Human PU.1 ETS-domain (165-270) in complex with d(AATAAGCGIAAGTGGG) 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*IP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), SODIUM ION, ... 著者 Terrell, J.R, Poon, G.M.K. 登録日 2023-06-26 公開日 2023-11-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors. Structure, 32, 2024
8T1K	DSBU crosslinked nNOS-CaM oxygenase homodimer 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ARGININE, Nitric oxide synthase 1, ... 著者 Lee, K, Pospiech, T.H, Southworth, D. 登録日 2023-06-02 公開日 2023-11-29 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.14 Å) 主引用文献 Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry. J.Biol.Chem., 300, 2023
8BZE	FC-J stabilizer for ERa and 14-3-3 分子名称: (2~{S},3~{R},4~{S},5~{S},6~{R})-2-[[(1~{E},3~{R},4~{S},8~{R},9~{R},10~{R},11~{S},14~{S})-14-(methoxymethyl)-3,10-dimethyl-4,9-bis(oxidanyl)-6-propan-2-yl-8-tricyclo[9.3.0.0^{3,7}]tetradeca-1,6-dienyl]oxy]-6-(2-methylbut-3-en-2-yloxymethyl)oxane-3,4,5-triol, 14-3-3 protein sigma, ERalpha peptide, ... 著者 Visser, E.J, Ottmann, C. 登録日 2022-12-14 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a new potential intervention strategy for endocrine resistance in breast cancer To Be Published
8BZD	deAc-FC stabilizer of 14-3-3 and ERalpha 分子名称: 14-3-3 protein sigma, De-acetylated Fusicoccin, ERalpha peptide, ... 著者 Visser, E.J, Ottmann, C. 登録日 2022-12-14 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
7BO7	CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437 分子名称: (2~{R},3~{R},4~{S},5~{R})-2-[(4~{a}~{S},7~{a}~{S})-4-azanyl-1,4,4~{a},7~{a}-tetrahydropyrrolo[2,3-d]pyrimidin-7-yl]-5-(quinolin-7-yloxymethyl)oxolane-3,4-diol, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Brown, D, Robinson, C, Carr, K.H, Pande, V. 登録日 2021-01-24 公開日 2022-03-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437 To Be Published
8BZT	FC-NAg stabilizer of 14-3-3 and ERalpha 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Ottmann, C. 登録日 2022-12-15 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
8BZH	FC-NAc stabilizer of 14-3-3 and ERalpha 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Ottmann, C. 登録日 2022-12-14 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
8BZG	FC-31 stabilizer of 14-3-3 and ERalpha 分子名称: 14-3-3 protein sigma, ERalpha peptide, Fusicoccin 31, ... 著者 Visser, E.J, Ottmann, C. 登録日 2022-12-14 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
8C0L	FC-THF stabilizer of 14-3-3 and ERalpha 分子名称: 14-3-3 protein sigma, ERalpha peptide, Fusicoccin A-THF 著者 Visser, E.J, Ottmann, C. 登録日 2022-12-17 公開日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
6DV5	Oligomeric complex of a Hsp27 24-mer at 3.6 A resolution 分子名称: Heat shock protein beta-1 著者 Aguda, A.H, Brayer, G.D. 登録日 2018-06-22 公開日 2019-06-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.58 Å) 主引用文献 Structure-Guided Discovery of Ivermectin as an Inhibitor of Heat Shock Protein-27 Phosphorylation and Depolymerization. To Be Published
7W8G	Cryo-EM structure of MCM double hexamer 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ... 著者 Cheng, J, Li, N, Tye, B, Zhai, Y, Gao, N. 登録日 2021-12-07 公開日 2022-04-13 実験手法 ELECTRON MICROSCOPY (2.52 Å) 主引用文献 Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase. Nat Commun, 13, 2022
8I0L	Structure of CDK9/cyclin T1 in complex with inhibitor 分子名称: 2-[(4-azanylcyclohexyl)amino]-7-cyclopentyl-~{N},~{N}-dimethyl-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Cyclin-T1, Cyclin-dependent kinase 9 著者 Jiang, C, Ye, Y, Huang, Y. 登録日 2023-01-11 公開日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structure of CDK9/cyclin T1 in complex with inhibitor To Be Published
7WQ4	Galanin-bound galanin receptor 2 in complex with Gq 分子名称: CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Galanin, ... 著者 Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. 登録日 2022-01-24 公開日 2022-04-20 最終更新日 2022-10-19 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
7WQ3	Galanin-bound galanin receptor 1 in complex with Gi 分子名称: CHOLESTEROL, Galanin, Galanin receptor type 1, ... 著者 Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. 登録日 2022-01-24 公開日 2022-04-20 最終更新日 2022-10-19 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
8D4U	Crystal Structure of Neutrophil Elastase Inhibited by Eap2 from S. aureus 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular Adherence Protein, ... 著者 Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V. 登録日 2022-06-02 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family. J.Biol.Chem., 299, 2023
8D4Q	Crystal Structure of Neutrophil Elastase Inhibited by Eap1 from S. aureus 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular Adherence Protein, Neutrophil elastase 著者 Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V. 登録日 2022-06-02 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family. J.Biol.Chem., 299, 2023
8Q5H	Human KMN network (outer kinetochore) 分子名称: Kinetochore protein Spc24, Kinetochore protein Spc25, Kinetochore scaffold 1, ... 著者 Raisch, T, Polley, S, Vetter, I, Musacchio, A, Raunser, S. 登録日 2023-08-09 公開日 2024-02-14 最終更新日 2024-09-04 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structure of the human KMN complex and implications for regulation of its assembly. Nat.Struct.Mol.Biol., 31, 2024
8IK5	Transcription factor LMX1a homeobox domain in complex with Wnt1 promoter 分子名称: DNA (5'-D(*CP*CP*AP*TP*AP*TP*TP*TP*AP*AP*TP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*GP*AP*TP*TP*AP*AP*AP*TP*AP*TP*G)-3'), GLYCEROL, ... 著者 Lv, M.Q, Lin, L.Q. 登録日 2023-02-28 公開日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.989 Å) 主引用文献 Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain Febs J., 2024
8IKE	Transcription factors LMX1a mutant-R199A homeobox domain complex with Wnt1 promoter 分子名称: DNA (5'-D(*CP*CP*AP*TP*AP*TP*TP*TP*AP*AP*TP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*GP*AP*TP*TP*AP*AP*AP*TP*AP*TP*G)-3'), LMX1A factor 著者 Lv, M.Q, Lin, L.Q. 登録日 2023-02-28 公開日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain Febs J., 2024
8IVU	Crystal Structure of Human NAMPT in complex with A4276 分子名称: N-[[4-(6-methyl-1,3-benzoxazol-2-yl)phenyl]methyl]pyridine-3-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION 著者 Kang, B.G, Cha, S.S. 登録日 2023-03-28 公開日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.09000921 Å) 主引用文献 Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy. Theranostics, 13, 2023
8TM7	Human NAMPT in complex with substrate NAM and small molecule activator NP-A3 分子名称: CHLORIDE ION, GLYCEROL, N-{2-[(4R)-2,2-dimethyl-4-(propan-2-yl)oxan-4-yl]ethyl}-N-[(4-methoxyphenyl)methyl]furan-2-carboxamide, ... 著者 Ratia, K.M, Thatcher, G.R. 登録日 2023-07-28 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. Acs Med.Chem.Lett., 15, 2024
8D7K	Bifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap2 from S. aureus 分子名称: Cathepsin G, C-terminal truncated form, Extracellular Adherence Protein, ... 著者 Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V. 登録日 2022-06-07 公開日 2023-06-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Bifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap2 from S. aureus To Be Published
6EF5	14-3-3 with peptide 分子名称: 14-3-3 protein zeta/delta, ARG-SER-LEU-SEP-ALA-PRO-GLY, LYS-LEU-SEP-LEU-GLN 著者 Dhagat, U, Langendorf, C.G, Parker, M.W.P, Oakhill, J.S, Scott, J.W. 登録日 2018-08-16 公開日 2019-10-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 14-3-3 with peptide To Be Published
1HD4	SOLUTION STRUCTURE OF THE A-SUBUNIT OF HUMAN CHORIONIC GONADOTROPIN [MODELED WITH DIANTENNARY GLYCAN AT ASN78] 分子名称: CHORIONIC GONADOTROPIN, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Erbel, P.J.A, Karimi-Nejad, Y, van Kuik, J.A, Boelens, R, Kamerling, J.P, Vliegenthart, J.F.G. 登録日 2000-11-07 公開日 2000-12-07 最終更新日 2020-07-29 実験手法 SOLUTION NMR 主引用文献 Effects of the N-Linked Glycans on the 3D Structure of the Free A-Subunit of Human Chorionic Gonadotropin Biochemistry, 39, 2000

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