8IVU

Crystal Structure of Human NAMPT in complex with A4276

Summary for 8IVU

• Entry DOI: 10.2210/pdb8ivu/pdb
• Descriptor: Nicotinamide phosphoribosyltransferase, N-[[4-(6-methyl-1,3-benzoxazol-2-yl)phenyl]methyl]pyridine-3-carboxamide, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: nampt, transferase, inhibitor, complex, cancer
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 224892.92

Authors

Kang, B.G.,Cha, S.S. (deposition date: 2023-03-28, release date: 2023-10-11)

• Primary citation: Kim, M.,Kim, H.,Kang, B.G.,Lee, J.,Kim, T.,Lee, H.,Jung, J.,Oh, M.J.,Seo, S.,Ryu, M.J.,Sung, Y.,Lee, Y.,Yeom, J.,Han, G.,Cha, S.S.,Jung, H.,Kim, H.S.; Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy.; Theranostics, 13:5075-5098, 2023; PubMed: 37771778; DOI: 10.7150/thno.85356

Experimental method

X-RAY DIFFRACTION (2.09000922463 Å)