8IVU

Crystal Structure of Human NAMPT in complex with A4276

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Nicotinamide phosphoribosyltransferase	polymer	491	55594.9	4	UniProt (P43490) Pfam (PF18127) Pfam (PF04095)	Homo sapiens (human)	NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	E, I, M, Q (A, B, C, D)	N-[[4-(6-methyl-1,3-benzoxazol-2-yl)phenyl]methyl]pyridine-3-carboxamide	non-polymer		343.4	4	Chemie (SJ6)
3	F, G, H, J, K... (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	12	Chemie (PO4)
4	U, V, W, X (A, B, C, D)	water	water		18.0	710	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	222379.8
Non-Polymers*	Number of molecules	16
	Total formula weight	2513.2
All*	Total formula weight	224892.9

*Water molecules are not included.