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7ZP5
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Crystal structure of designed photoenzyme EnT1.0
分子名称: Diisopropyl-fluorophosphatase, PHOSPHATE ION
著者Hardy, F.J, Levy, C.
登録日2022-04-26
公開日2022-09-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献A designed photoenzyme for enantioselective [2+2] cycloadditions.
Nature, 611, 2022
7ZP2
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Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum in complex with BDA-04
分子名称: Aspartate carbamoyltransferase, SODIUM ION, SULFATE ION, ...
著者Wang, C, Zhang, B, Groves, M.R.
登録日2022-04-26
公開日2022-08-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.292 Å)
主引用文献Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials.
J.Am.Chem.Soc., 144, 2022
7ZOZ
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Crystal structure of Siglec-15 in complex with Fab
分子名称: Anti-Siglec 15 Fab HC, Anti-Siglec 15 Fab LC, Sialic acid-binding Ig-like lectin 15
著者Lenza, M.P, Oyenarte, I, Jimenez-Barbero, J, Ereno-Orbea, J.
登録日2022-04-26
公開日2023-06-28
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.104 Å)
主引用文献Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b.
Nat Commun, 14, 2023
7ZOY
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Crystal structure of Synechocystis halorhodopsin (SyHR), SO4-bound form, ground state
分子名称: CHLORIDE ION, EICOSANE, GLYCEROL, ...
著者Kovalev, K, Bukhdruker, S, Astashkin, R, Vaganova, S, Gordeliy, V.
登録日2022-04-26
公開日2022-11-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Structural insights into light-driven anion pumping in cyanobacteria.
Nat Commun, 13, 2022
7ZOR
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Crystal structure of anti-Siglec-15 Fab
分子名称: Anti-siglec15 FAB HC, Anti-siglec15 FAB LC
著者Lenza, M.P, Oyenarte, I, Jimenez-Barbero, J, Ereno-Orbea, J.
登録日2022-04-26
公開日2023-06-28
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.933 Å)
主引用文献Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b.
Nat Commun, 14, 2023
7ZOG
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Crystal structure of Cryptosporidium parvum -Plasmodium falciparum mutant lysyl tRNA synthetase in complex with inhibitor
分子名称: 8-[[4-[2-[2-[2-[2-[(azanylidene-$l^{4}-azanylidene)amino]ethoxy]ethoxy]ethoxy]ethylcarbamoyl]phenyl]sulfonylamino]-~{N}-(cyclohexylmethyl)-6-fluoranyl-4-oxidanylidene-chromene-2-carboxamide, GLYCEROL, LYSINE, ...
著者Dawson, A, Wyllie, S.
登録日2022-04-25
公開日2022-09-07
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase.
Acs Infect Dis., 8, 2022
7ZOF
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Streptavidin Iron-Porphyrin
分子名称: (2R)-2-[5-[(3aS,4S,6aR)-2-oxidanylidene-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-[[(5Z,10Z,14Z,19Z)-15-[[[(2R)-2-[5-[(3aS,4S,6aR)-2-oxidanylidene-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-sulfo-propanoyl]amino]methyl]-1,4,21,23-tetrahydroporphyrin-5-yl]methylamino]-3-oxidanylidene-propane-1-sulfonic acid, FE (III) ION, IMIDAZOLE, ...
著者Igareta, N.V, Ward, T.R.
登録日2022-04-25
公開日2022-07-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Streptavidin Iron-Porphyrin
To Be Published
7ZOC
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Crystal structure of the peptidase domain of collagenase H from Clostridium histolyticum in complex with N-aryl-2-alkylmercaptoacetamide-based inhibitor
分子名称: CALCIUM ION, Collagenase ColH, ZINC ION, ...
著者Schoenauer, E, Brandstetter, H.
登録日2022-04-25
公開日2023-05-10
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH
Chemrxiv, 2022
7ZOB
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Metagenomic cytidine deaminase Cdd
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Metagenomic cytidine deaminase Cdd, SULFATE ION, ...
著者Tamulaitiene, G, Urbeliene, N, Meskys, R.
登録日2022-04-25
公開日2023-02-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Cytidine deaminases catalyze the conversion of N ( S , O ) 4 -substituted pyrimidine nucleosides.
Sci Adv, 9, 2023
7ZO7
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L1 metallo-beta-lactamase in complex with hydrolysed cefmetazole
分子名称: (2R,5R)-2-[(1S)-1-[2-(cyanomethylsulfanyl)ethanoylamino]-1-methoxy-2-oxidanyl-2-oxidanylidene-ethyl]-5-[(1-methyl-1,2,3,4-tetrazol-5-yl)sulfanylmethyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Metallo-beta-lactamase L1, SULFATE ION, ...
著者Hinchliffe, P, Spencer, J.
登録日2022-04-24
公開日2023-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Interactions of hydrolyzed beta-lactams with the L1 metallo-beta-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.
J.Biol.Chem., 299, 2023
7ZO6
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L1 metallo-beta-lactamase in complex with hydrolysed cefoxitin
分子名称: (2~{R},5~{S})-5-(aminocarbonyloxymethyl)-2-[(1~{S})-1-methoxy-2-oxidanyl-2-oxidanylidene-1-(2-thiophen-2-ylethanoylamino)ethyl]-5,6-dihydro-2~{H}-1,3-thiazine-4-carboxylic acid, Metallo-beta-lactamase L1, SULFATE ION, ...
著者Hinchliffe, P, Spencer, J.
登録日2022-04-24
公開日2023-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Interactions of hydrolyzed beta-lactams with the L1 metallo-beta-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.
J.Biol.Chem., 299, 2023
7ZO5
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L1 metallo-beta-lactamase in complex with a mecillinam degradation product
分子名称: (2~{R},4~{S})-2-[(1~{R})-2-(azepan-1-yl)-1-formamido-2-oxidanylidene-ethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Metallo-beta-lactamase L1, SULFATE ION, ...
著者Hinchliffe, P, Spencer, J.
登録日2022-04-24
公開日2023-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Interactions of hydrolyzed beta-lactams with the L1 metallo-beta-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.
J.Biol.Chem., 299, 2023
7ZO4
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L1 metallo-beta-lactamase in complex with hydrolysed panipenem
分子名称: (2R,4S)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3S)-1-ethanimidoylpyrrolidin-3-yl]sulfanyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Metallo-beta-lactamase L1, SODIUM ION, ...
著者Hinchliffe, P, Spencer, J.
登録日2022-04-24
公開日2023-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Interactions of hydrolyzed beta-lactams with the L1 metallo-beta-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.
J.Biol.Chem., 299, 2023
7ZO3
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L1 metallo-beta-lactamase in complex with hydrolysed tebipenem
分子名称: (2S,3R,4S)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Metallo-beta-lactamase L1, SULFATE ION, ...
著者Hinchliffe, P, Spencer, J.
登録日2022-04-24
公開日2023-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Interactions of hydrolyzed beta-lactams with the L1 metallo-beta-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.
J.Biol.Chem., 299, 2023
7ZO2
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L1 metallo-beta-lactamase complex with hydrolysed doripenem
分子名称: (2~{S},3~{R},4~{S})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-3-methyl-4-[(3~{S},5~{S})-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, CHLORIDE ION, Metallo-beta-lactamase L1, ...
著者Hinchliffe, P, Spencer, J.
登録日2022-04-24
公開日2023-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Interactions of hydrolyzed beta-lactams with the L1 metallo-beta-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.
J.Biol.Chem., 299, 2023
7ZO0
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Crystal structure of catalytic inactive unliganded form of FucOB, a GH95 family alpha-1,2-fucosidase from Akkermansia muciniphila
分子名称: GH95 family alpha-1,2-fucosidase, GLYCEROL
著者Anso, I, Cifuente, J.O, Trastoy, B, Guerin, M.E.
登録日2022-04-23
公開日2023-04-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Turning universal O into rare Bombay type blood.
Nat Commun, 14, 2023
7ZNZ
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Crystal structure of unliganded form of FucOB, a GH95 family alpha-1,2-fucosidase from Akkermansia muciniphila
分子名称: FucOB, a GH95 family alpha-1,2-fucosidase, GLYCEROL
著者Anso, I, Cifuente, J.O, Trastoy, B, Guerin, M.E.
登録日2022-04-23
公開日2023-04-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Turning universal O into rare Bombay type blood.
Nat Commun, 14, 2023
7ZNY
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Cryo-EM structure of the canine distemper virus tetrameric attachment glycoprotein
分子名称: Hemagglutinin glycoprotein
著者Kalbermatter, D, Jeckelmann, J.-M, Wyss, M, Plattet, P, Fotiadis, D.
登録日2022-04-23
公開日2023-02-08
最終更新日2023-02-15
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Structure and supramolecular organization of the canine distemper virus attachment glycoprotein.
Proc.Natl.Acad.Sci.USA, 120, 2023
7ZNX
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Crystal structure of cocaprin 1, inhibitor of cysteine and aspartic proteases from Coprinopsis cinerea
分子名称: Cocaprin 1
著者Renko, M, Turk, D, Sabotic, J.
登録日2022-04-22
公開日2022-06-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Cocaprins, beta-Trefoil Fold Inhibitors of Cysteine and Aspartic Proteases from Coprinopsis cinerea.
Int J Mol Sci, 23, 2022
7ZNF
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ALTERNATING ZINC FINGERS IN THE HUMAN MALE ASSOCIATED PROTEIN ZFY: 2D NMR STRUCTURE OF AN EVEN FINGER AND IMPLICATIONS FOR "JUMPING-LINKER" DNA RECOGNITION
分子名称: ZINC FINGER, ZINC ION
著者Kochoyan, M, Keutmann, H.T, Weiss, M.A.
登録日1991-08-22
公開日1994-01-31
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition.
Biochemistry, 30, 1991
7ZN6
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Crystal structure of laccase-like multicopper oxidase (LMCO) from Thermothelomyces thermophilus
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Kosinas, C, Dimarogona, M, Zerva, A, Topakas, E.
登録日2022-04-20
公開日2023-06-28
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure-function studies of a novel laccase-like multicopper oxidase from Thermothelomyces thermophila provide insights into its biological role.
Acta Crystallogr D Struct Biol, 79, 2023
7ZMX
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Crystal structure of the Plant Homeodomain (PHD) of human ING3
分子名称: CALCIUM ION, Inhibitor of growth protein 3, ZINC ION
著者Ferreras, M.O, Medrano, F.J, Blanco, F.J.
登録日2022-04-20
公開日2023-05-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structural analysis of ING3 protein and histone H3 binding.
Int.J.Biol.Macromol., 242, 2023
7ZMV
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Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G5-006
分子名称: ATP-dependent DNA helicase Q5, Gluebody G5-006, SULFATE ION, ...
著者Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F.
登録日2022-04-19
公開日2022-06-22
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.002 Å)
主引用文献Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts
To Be Published
7ZMT
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Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G5-006
分子名称: ATP-dependent DNA helicase Q5, Gluebody G5-006, ZINC ION
著者Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F.
登録日2022-04-19
公開日2022-06-22
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts
To Be Published
7ZMS
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Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G4-043
分子名称: ATP-dependent DNA helicase Q5, Gluebody G4-043, ZINC ION
著者Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F.
登録日2022-04-19
公開日2022-07-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts
To Be Published

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