7ZOG

Crystal structure of Cryptosporidium parvum -Plasmodium falciparum mutant lysyl tRNA synthetase in complex with inhibitor

Summary for 7ZOG

Entry DOI	10.2210/pdb7zog/pdb
Descriptor	Lysine-tRNA ligase, 8-[[4-[2-[2-[2-[2-[(azanylidene-$l^{4}-azanylidene)amino]ethoxy]ethoxy]ethoxy]ethylcarbamoyl]phenyl]sulfonylamino]-~{N}-(cyclohexylmethyl)-6-fluoranyl-4-oxidanylidene-chromene-2-carboxamide, GLYCEROL, ... (5 entities in total)
Functional Keywords	trna binding, ligase
Biological source	Cryptosporidium parvum Iowa II
Total number of polymer chains	4
Total formula weight	249812.81
Authors	Dawson, A.,Wyllie, S. (deposition date: 2022-04-25, release date: 2022-09-07, Last modification date: 2024-01-31)
Primary citation	Milne, R.,Wiedemar, N.,Corpas-Lopez, V.,Moynihan, E.,Wall, R.J.,Dawson, A.,Robinson, D.A.,Shepherd, S.M.,Smith, R.J.,Hallyburton, I.,Post, J.M.,Dowers, K.,Torrie, L.S.,Gilbert, I.H.,Baragana, B.,Patterson, S.,Wyllie, S. Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase. Acs Infect Dis., 8:1962-1974, 2022 Cited by PubMed: 36037410 DOI: 10.1021/acsinfecdis.2c00364 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation