7ZOG
Crystal structure of Cryptosporidium parvum -Plasmodium falciparum mutant lysyl tRNA synthetase in complex with inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Lysine-tRNA ligase | polymer | 535 | 61464.1 | 4 | UniProt (Q5CR27) Pfam (PF01336) Pfam (PF00152) In PDB | Cryptosporidium parvum Iowa II | Lysyl-tRNA synthetase |
2 | A, B, C, D | LYSINE | non-polymer | 147.2 | 4 | Chemie (LYS) | |||
3 | A, B, C, D | 8-[[4-[2-[2-[2-[2-[(azanylidene-$l^{4}-azanylidene)amino]ethoxy]ethoxy]ethoxy]ethylcarbamoyl]phenyl]sulfonylamino]-~{N}-(cyclohexylmethyl)-6-fluoranyl-4-oxidanylidene-chromene-2-carboxamide | non-polymer | 703.8 | 4 | Chemie (JE5) | |||
4 | A, B, C, D | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
5 | water | water | 18.0 | 1465 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 46 - 559 (UniProt: Q5CR27)
PDB | External Database | Details |
---|---|---|
Met 25 | - | initiating methionine |
Ala 26 | - | expression tag |
His 27 | - | expression tag |
His 28 | - | expression tag |
His 29 | - | expression tag |
His 30 | - | expression tag |
His 31 | - | expression tag |
His 32 | - | expression tag |
Met 33 | - | expression tag |
Gly 34 | - | expression tag |
Thr 35 | - | expression tag |
Leu 36 | - | expression tag |
Glu 37 | - | expression tag |
Ala 38 | - | expression tag |
Gln 39 | - | expression tag |
Thr 40 | - | expression tag |
Gln 41 | - | expression tag |
Gly 42 | - | expression tag |
Pro 43 | - | expression tag |
Gly 44 | - | expression tag |
Ser 45 | - | expression tag |
Thr 272 | Pro 272 | engineered mutation |
Val 293 | Asn 293 | engineered mutation |
Ser 309 | Ala 309 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 245856.4 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 3956.4 | |
All* | Total formula weight | 249812.8 |