8P4Z
| Crystal structure of the human CDK7 kinase domain in complex with LDC4297 | 分子名称: | 2-[(3R)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine, Cyclin-dependent kinase 7, GLYCEROL, ... | 著者 | Laursen, M, Caing-Carlsson, R, Houssari, R, Javadi, A, Kimbung, Y.R, Murina, V, Orozco-Rodriguez, J.M, Svensson, A, Welin, M, Logan, D, Svensson, B, Walse, B. | 登録日 | 2023-05-23 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal structure of the human CDK7 kinase domain in complex with LDC4297 To Be Published
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8UV0
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5X17
| Crystal structure of murine CK1d in complex with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Casein kinase I isoform delta, SULFATE ION | 著者 | Kikuchi, M, Shinohara, Y, Ueda, H.R, Umehara, T. | 登録日 | 2017-01-25 | 公開日 | 2017-10-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock Mol. Cell, 67, 2017
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5WNK
| Crystal structure of murine receptor-interacting protein 4 (Ripk4) D143N bound to TG100-115 | 分子名称: | 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol, CHLORIDE ION, Receptor-interacting serine/threonine-protein kinase 4 | 著者 | Huang, C.S, Hymowitz, S.G. | 登録日 | 2017-08-01 | 公開日 | 2018-05-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity. Structure, 26, 2018
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5W7T
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5WDY
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5WNF
| X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR | 分子名称: | 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-N-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1H-1,2,3-triazole-4-carboxamide, GLYCEROL, Rho-associated protein kinase 1 | 著者 | Li, X. | 登録日 | 2017-07-31 | 公開日 | 2018-08-01 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Novel mechanism of Rho kinase selectivity: beyond the ATP pocket To Be Published
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8OY2
| Human cyclin-dependent kinase 2 in complex with inhibitor HB-29260 | 分子名称: | (1S,2S,11aS)-1-methoxy-1,4,7,10-tetramethyl-2,9-bis(oxidanyl)-2,11a-dihydrobenzo[b][1,4]benzodioxepine-3,6-dione, Cyclin-dependent kinase 2, GLYCEROL | 著者 | Kordes, S, Harvey, C.J.B. | 登録日 | 2023-05-03 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.618 Å) | 主引用文献 | Resistance gene-guided genome mining reveals the roseopurpurins as inhibitors of cyclin-dependent kinases. Proc.Natl.Acad.Sci.USA, 120, 2023
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5WP1
| Complex of ERK2 with 5,7-dihydroxychromone | 分子名称: | 5,7-dihydroxy-4H-1-benzopyran-4-one, BENZOIC ACID, Mitogen-activated protein kinase 1, ... | 著者 | Kurinov, I, Malakhova, M. | 登録日 | 2017-08-03 | 公開日 | 2018-08-08 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Multiple phytochemicals at low doses accumulatively inhibit one key protein in cancers To Be Published
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5WNI
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8OKU
| Salt-Inducible Kinase 3 in complex with an inhibitor | 分子名称: | Serine/threonine-protein kinase SIK3, ~{N}-ethyl-4-[5-[1-(2-hydroxyethyl)pyrazol-4-yl]benzimidazol-1-yl]-2,6-dimethoxy-benzamide | 著者 | Flower, T.G, Leonard, P.M, Lamers, M.B.A.C, Mollat, P. | 登録日 | 2023-03-29 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312. J.Med.Chem., 67, 2024
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5X1T
| PpkA-294 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, PpkA-294 | 著者 | Li, P.P, Ran, T.T, Xu, D.Q, Wang, W.W. | 登録日 | 2017-01-26 | 公開日 | 2018-01-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism. Biochem.J., 475, 2018
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5X18
| Crystal structure of Casein kinase I homolog 1 | 分子名称: | Casein kinase I homolog 1, GLYCEROL, MALONIC ACID | 著者 | Kikuchi, M, Shinohara, Y, Ueda, H.R, Umehara, T. | 登録日 | 2017-01-25 | 公開日 | 2017-10-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock Mol. Cell, 67, 2017
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5X1Q
| PpkA-294 with ATP and MnCl2 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Li, P.P, Ran, T.T, Xu, D.Q, Wang, W.W. | 登録日 | 2017-01-26 | 公開日 | 2018-01-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | 主引用文献 | Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism. Biochem.J., 475, 2018
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5X1S
| PpkA-294 with Amppcp | 分子名称: | GLYCEROL, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, PpkA | 著者 | Li, P.P, Ran, T.T, Xu, D.Q, Wang, W.W. | 登録日 | 2017-01-26 | 公開日 | 2018-01-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism. Biochem.J., 475, 2018
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8OF5
| Crystal structure of Aurora A 122-403 C290A, N332A, Q335A, C393A bound to ADP | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Miles, J.A, Hammond, K.L.R, Bayliss, R. | 登録日 | 2023-03-14 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Crystal structure of Aurora A 122-403 C290A, N332A, Q335A, C393A bound to ADP To Be Published
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5XKA
| Crystal structure of M.tuberculosis PknI kinase domain | 分子名称: | Serine/threonine-protein kinase PknI | 著者 | Yan, Q, Jiang, D, Qian, L, Zhang, Q, Zhang, W, Zhou, W, Mi, K, Guddat, L, Yang, H, Rao, Z. | 登録日 | 2017-05-06 | 公開日 | 2018-05-16 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | Structural Insight into the Activation of PknI Kinase from M. tuberculosis via Dimerization of the Extracellular Sensor Domain. Structure, 25, 2017
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5XVA
| Crystal Structure of PAK4 in complex with inhibitor CZH216 | 分子名称: | ETHANOL, Serine/threonine-protein kinase PAK 4, [6-chloranyl-4-[(5-methyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]-[(3R)-3-methylpiperazin-1-yl]methanone | 著者 | Zhao, F, Li, H. | 登録日 | 2017-06-27 | 公開日 | 2018-02-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.847 Å) | 主引用文献 | Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors. J. Med. Chem., 61, 2018
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5XVG
| Crystal Structure of PAK4 in complex with inhibitor CZH226 | 分子名称: | 1,2-ETHANEDIOL, ETHANOL, Serine/threonine-protein kinase PAK 4, ... | 著者 | Zhao, F, Li, H. | 登録日 | 2017-06-27 | 公開日 | 2018-02-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors. J. Med. Chem., 61, 2018
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8Q1Z
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5X8I
| Crystal structure of human CLK1 in complex with compound 25 | 分子名称: | 5-[1-[(1S)-1-(4-fluorophenyl)ethyl]-[1,2,3]triazolo[4,5-c]quinolin-8-yl]-1,3-benzoxazole, Dual specificity protein kinase CLK1 | 著者 | Sun, Q.Z, Lin, G.F, Li, L.L, Jin, X.T, Huang, L.Y, Zhang, G, Wei, Y.Q, Lu, G.W, Yang, S.Y. | 登録日 | 2017-03-02 | 公開日 | 2017-08-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | 主引用文献 | Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers J. Med. Chem., 60, 2017
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8PVP
| Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric compound FGJG18 | 分子名称: | CSNK2A1 protein, SULFATE ION, ~{N}-[5-[(3-chloranyl-4-phenyl-phenyl)methylamino]pentyl]isoquinoline-5-sulfonamide | 著者 | Kraemer, A, Greco, F, Gerninghaus, J, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2023-07-18 | 公開日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric compound FGJG18 To Be Published
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8PVO
| Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric compound FG5 | 分子名称: | 1,2-ETHANEDIOL, 2-[1-(1,3-benzothiazol-6-ylsulfonyl)piperidin-4-yl]-~{N}-[(3-chloranyl-4-phenyl-phenyl)methyl]ethanamine, CSNK2A1 protein, ... | 著者 | Kraemer, A, Greco, F, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2023-07-18 | 公開日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric compound FG5 To Be Published
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8PM3
| Crystal structure of MAP2K6 with a covalent compound GCL94 | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 6, ~{N}-[3-(2-azanylpyridin-4-yl)phenyl]propanamide | 著者 | Wang, G.Q, Seidler, N, Roehm, S, Gehringer, M, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2023-06-28 | 公開日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of MAP2K6 with a covalent compound GCL94 To Be Published
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8QLQ
| Human MST3 (STK24) kinase in complex with macrocyclic inhibitor JA310 | 分子名称: | 1,2-ETHANEDIOL, Serine/threonine-protein kinase 24, macrocyclic inhibitor | 著者 | Balourdas, D.I, Amrhein, J.A, Hanke, T, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | 登録日 | 2023-09-20 | 公開日 | 2023-11-08 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. J.Med.Chem., 67, 2024
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