5G6V

Crystal structure of the PCTAIRE1 kinase in complex with inhibitor

Summary for 5G6V

Entry DOI	10.2210/pdb5g6v/pdb
Descriptor	CYCLIN-DEPENDENT KINASE 16, 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: Q00536
Total number of polymer chains	2
Total formula weight	75973.02
Authors	Dixon-Clarke, S.E.,Galan Bartual, S.,Elkins, J.,Savitsky, P.,Kopec, J.,Mackenzie, A.,Tallant, C.,Heroven, C.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2016-08-16, release date: 2016-11-23, Last modification date: 2023-08-02)
Primary citation	Dixon-Clarke, S.E.,Shehata, S.N.,Krojer, T.,Sharpe, T.D.,von Delft, F.,Sakamoto, K.,Bullock, A.N. Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16. Biochem.J., 474:699-713, 2017 Cited by PubMed: 28057719 DOI: 10.1042/BCJ20160941 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation