5EOL

Crystal structure of human Pim-1 kinase in complex with a macrocyclic quinoxaline-pyrrolodihydropiperidinone inhibitor

Summary for 5EOL

Entry DOI	10.2210/pdb5eol/pdb
Descriptor	Serine/threonine-protein kinase pim-1, macrocyclic quinoxaline-pyrrolodihydropiperidinone, GLYCEROL, ... (4 entities in total)
Functional Keywords	transferase, serine/threonine protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	33608.03
Authors	Mohr, C. (deposition date: 2015-11-10, release date: 2016-05-04, Last modification date: 2024-03-06)
Primary citation	Cee, V.J.,Chavez, F.,Herberich, B.,Lanman, B.A.,Pettus, L.H.,Reed, A.B.,Wu, B.,Wurz, R.P.,Andrews, K.L.,Chen, J.,Hickman, D.,Laszlo, J.,Lee, M.R.,Guerrero, N.,Mattson, B.K.,Nguyen, Y.,Mohr, C.,Rex, K.,Sastri, C.E.,Wang, P.,Wu, Q.,Wu, T.,Xu, Y.,Zhou, Y.,Winston, J.T.,Lipford, J.R.,Tasker, A.S.,Wang, H.L. Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors. Acs Med.Chem.Lett., 7:408-412, 2016 Cited by PubMed: 27096050 DOI: 10.1021/acsmedchemlett.5b00403 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation