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7XZ5
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GPR119-Gs-LPC complex
分子名称: (4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, P, Huang, S, Jiang, Y, Xu, H.E.
登録日2022-06-02
公開日2022-08-24
最終更新日2022-10-05
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119.
Nat.Struct.Mol.Biol., 29, 2022
7UL5
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CryoEM Structure of Inactive SSTR2 bound to Nb6
分子名称: Nanobody 6, Somatostatin receptor type 2
著者Robertson, M.J, Skiniotis, G.
登録日2022-04-03
公開日2022-06-29
最終更新日2022-12-28
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structure determination of inactive-state GPCRs with a universal nanobody.
Nat.Struct.Mol.Biol., 29, 2022
7Y13
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Cryo-EM structure of apo-state MrgD-Gi complex (local)
分子名称: PALMITIC ACID, Soluble cytochrome b562,Mas-related G-protein coupled receptor member D
著者Suzuki, S, Iida, M, Kawamoto, A, Oshima, A.
登録日2022-06-06
公開日2022-07-20
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM.
Commun Biol, 5, 2022
5ZHP
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M3 muscarinic acetylcholine receptor in complex with a selective antagonist
分子名称: (1R,2R,4S,5S,7s)-7-({[4-fluoro-2-(thiophen-2-yl)phenyl]carbamoyl}oxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]nonan-9-ium, CITRIC ACID, HEXAETHYLENE GLYCOL, ...
著者Liu, H, Hofmann, J, Fish, I, Schaake, B, Eitel, K, Bartuschat, A, Kaindl, J, Rampp, H, Banerjee, A, Hubner, H, Clark, M.J, Vincent, S.G, Fisher, J, Heinrich, M, Hirata, K, Liu, X, Sunahara, R.K, Shoichet, B.K, Kobilka, B.K, Gmeiner, P.
登録日2018-03-13
公開日2018-11-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7RKX
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Structure of US27-Gi-scFv16 in CL-state
分子名称: Antibody fragment scFv16, G-protein coupled receptor homolog US27, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Tsutsumi, N, Jude, K.M, Garcia, K.C.
登録日2021-07-22
公開日2022-01-26
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7XKA
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Structure of human beta2 adrenergic receptor bound to constrained epinephrine
分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Camelid Antibody Fragment, Endolysin,Beta-2 adrenergic receptor, ...
著者Xu, X, Shonberg, J, Kaindl, J, Clark, M, Stobel, A, Maul, L, Mayer, D, Hubner, H, Venkatakrishnan, A, Dror, R, Kobilka, B.K, Sunahara, R, Liu, X, Gmeiner, P.
登録日2022-04-19
公開日2023-04-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Constrained catecholamines gain beta 2 AR selectivity through allosteric effects on pocket dynamics.
Nat Commun, 14, 2023
4RWS
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Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target)
分子名称: C-X-C chemokine receptor type 4/Endolysin chimeric protein, Viral macrophage inflammatory protein 2
著者Qin, L, Kufareva, I, Holden, L, Wang, C, Zheng, Y, Wu, H, Fenalti, G, Han, G.W, Cherezov, V, Abagyan, R, Stevens, R.C, Handel, T.M, GPCR Network (GPCR)
登録日2014-12-05
公開日2015-02-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine.
Science, 347, 2015
7Y12
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Cryo-EM structure of MrgD-Gi complex with beta-alanine
分子名称: BETA-ALANINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Suzuki, S, Iida, M, Kawamoto, A, Oshima, A.
登録日2022-06-06
公開日2022-07-20
最終更新日2023-02-15
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM.
Commun Biol, 5, 2022
7XT8
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Serotonin 4 (5-HT4) receptor-Gs-Nb35 complex
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
登録日2022-05-16
公開日2022-07-27
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
6OBA
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The beta2 adrenergic receptor bound to a negative allosteric modulator
分子名称: (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, 6-bromo-N~2~-phenylquinazoline-2,4-diamine, Beta-2 adrenergic receptor,Lysozyme,Beta-2 adrenergic receptor, ...
著者Liu, X, Stobel, A, Kaindl, J, Dengler, D, ClarK, M, Mahoney, J, Korczynska, M, Matt, R.A, Hubner, H, Xu, X, Stanek, M, Hirata, K, Shoichet, B, Sunahara, R, Gmeiner, R, Kobilka, B.K.
登録日2019-03-20
公開日2020-03-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献An allosteric modulator binds to a conformational hub in the beta2adrenergic receptor.
Nat.Chem.Biol., 16, 2020
3OE8
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Crystal structure of the CXCR4 chemokine receptor in complex with a small molecule antagonist IT1t in P1 spacegroup
分子名称: (6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate, C-X-C chemokine receptor type 4, Lysozyme Chimera
著者Wu, B, Mol, C.D, Han, G.W, Katritch, V, Chien, E.Y.T, Liu, W, Cherezov, V, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
登録日2010-08-12
公開日2010-10-27
最終更新日2021-10-06
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Science, 330, 2010
8GFV
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CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #1 of 20)
分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Papasergi-Scott, M.M, Skiniotis, G.
登録日2023-03-08
公開日2024-03-06
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
7RMH
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Substance P bound to active human neurokinin 1 receptor in complex with miniGs399
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A.
登録日2021-07-27
公開日2021-11-03
最終更新日2022-01-05
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Selective G protein signaling driven by substance P-neurokinin receptor dynamics.
Nat.Chem.Biol., 18, 2022
7CKZ
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Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling complex
分子名称: 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ...
著者Yan, W, Shao, Z.
登録日2020-07-20
公開日2021-03-03
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
8THL
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Cryo-EM structure of epinephrine-bound alpha-1A-adrenergic receptor in complex with heterotrimeric Gq-protein
分子名称: Endolysin,Alpha-1A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Su, M, Huang, X.Y.
登録日2023-07-17
公開日2023-08-16
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of agonist specificity of alpha 1A -adrenergic receptor.
Nat Commun, 14, 2023
7E2Z
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Aripiprazole-bound serotonin 1A (5-HT1A) receptor-Gi protein complex
分子名称: 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E.
登録日2021-02-07
公開日2021-04-14
最終更新日2021-04-28
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into the lipid and ligand regulation of serotonin receptors.
Nature, 592, 2021
5OLO
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BU of 5olo by Molmil
Structure of the A2A-StaR2-bRIL562-Tozadenant complex at 3.1A obtained from in meso soaking experiments.
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ...
著者Rucktooa, P, Cheng, R.K.Y, Segala, E, Geng, T, Errey, J.C, Brown, G.A, Cooke, R, Marshall, F.H, Dore, A.S.
登録日2017-07-28
公開日2018-01-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals.
Sci Rep, 8, 2018
8U1U
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Structure of a class A GPCR/agonist complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C-C motif chemokine 1,C-C chemokine receptor type 8,EGFP fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Sun, D, Johnson, M, Masureel, M.
登録日2023-09-02
公開日2023-12-20
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8.
Nat Commun, 14, 2023
7WVW
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Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2
分子名称: FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
登録日2022-02-11
公開日2022-04-13
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
7YFD
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Cryo-EM structure of the imetit-bound histamine H4 receptor and Gq complex
分子名称: 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate, CHOLESTEROL, Engineered G-alpha-q, ...
著者Im, D, Iwata, S, Asada, H.
登録日2022-07-08
公開日2023-10-25
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into the agonists binding and receptor selectivity of human histamine H 4 receptor.
Nat Commun, 14, 2023
7XOW
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Structural insights into human brain gut peptide cholecystokinin receptors
分子名称: Gastrin, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S.
登録日2022-05-01
公開日2022-07-20
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into human brain-gut peptide cholecystokinin receptors.
Cell Discov, 8, 2022
7XMR
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CryoEM structure of the somatostatin receptor 2 (SSTR2) in complex with Gi1 and its endogeneous peptide ligand SST-14
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Wenli, Z, Shuo, H, Na, Q, Wenbo, Z, Mengjie, L, Dehua, Y, Ming-Wei, W, Wu, B, Zhao, Q.
登録日2022-04-26
公開日2022-08-03
最終更新日2022-08-17
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into ligand recognition and selectivity of somatostatin receptors.
Cell Res., 32, 2022
6DRX
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Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5HT2B receptor, BRIL chimera, ...
著者McCorvy, J.D, Wacker, D, Wang, S, Agegnehu, B, Liu, J, Lansu, K, Tribo, A.R, Olsen, R.H.J, Che, T, Jin, J, Roth, B.L.
登録日2018-06-13
公開日2018-08-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
6DRZ
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Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (8alpha)-N-[(2S)-1-hydroxybutan-2-yl]-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide, 5HT2B receptor, ...
著者McCorvy, J.D, Wacker, D, Wang, S, Agegnehu, B, Liu, J, Lansu, K, Tribo, A.R, Olsen, R.H.J, Che, T, Jin, J, Roth, B.L.
登録日2018-06-13
公開日2018-08-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.102 Å)
主引用文献Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
8XJO
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U46619 bound Thromboxane A2 receptor-Gq Protein Complex
分子名称: (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ...
著者Zhang, X, Li, X, Liu, G, Gong, W.
登録日2023-12-21
公開日2024-02-28
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.11 Å)
主引用文献Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024

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