6LUQ

Haloperidol bound D2 dopamine receptor structure inspired discovery of subtype selective ligands

Summary for 6LUQ

• Entry DOI: 10.2210/pdb6luq/pdb
• Descriptor: chimera of D(2) dopamine receptor and Endolysin, 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one, OLEIC ACID, ... (4 entities in total)
• Functional Keywords: gpcr, dopamine receptor, haloperidol, d2 dopamine receptor, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 50385.11

Authors

Fan, L.,Tan, L.,Chen, Z.,Qi, J.,Nie, F.,Luo, Z.,Cheng, J.,Wang, S. (deposition date: 2020-01-30, release date: 2020-03-04, Last modification date: 2023-11-29)

• Primary citation: Fan, L.,Tan, L.,Chen, Z.,Qi, J.,Nie, F.,Luo, Z.,Cheng, J.,Wang, S.; Haloperidol bound D2dopamine receptor structure inspired the discovery of subtype selective ligands.; Nat Commun, 11:1074-1074, 2020; PubMed: 32103023; DOI: 10.1038/s41467-020-14884-y

Experimental method

X-RAY DIFFRACTION (3.1 Å)