6LUQ
Haloperidol bound D2 dopamine receptor structure inspired discovery of subtype selective ligands
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | chimera of D(2) dopamine receptor and Endolysin | polymer | 430 | 48879.4 | 1 | UniProt (P14416) UniProt (D9IEF7) Pfam (PF00001) Pfam (PF00959) | Homo sapiens (Human) | Dopamine D2 receptor,Lysis protein,Lysozyme,Muramidase |
| 2 | B (A) | 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one | non-polymer | 375.9 | 1 | Chemie (GMJ) | Haloperidol | ||
| 3 | C, D, E, F (A) | OLEIC ACID | non-polymer | 282.5 | 4 | Chemie (OLA) | |||
| 4 | G (A) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 35 - 222 (UniProt: P14416)
A: 223 - null (UniProt: D9IEF7)
A: 388 - 464 (UniProt: P14416)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Ile 122 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr 275 | Cys 54 | conflict |
| Ala 318 | Cys 97 | conflict |
| Leu | - | linker |
| Ser | - | linker |
| Gln | - | linker |
| Gln 387 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 396 | Leu 375 | conflict |
| Ala 400 | Leu 379 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48879.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1505.7 | |
| All* | Total formula weight | 50385.1 |
