2AL5
| Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with fluoro-willardiine and aniracetam | 分子名称: | 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE, 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2 | 著者 | Jin, R, Clark, S, Weeks, A.M, Dudman, J.T, Gouaux, E, Partin, K.M. | 登録日 | 2005-08-04 | 公開日 | 2005-10-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Mechanism of positive allosteric modulators acting on AMPA receptors. J.Neurosci., 25, 2005
|
|
2AXT
| Crystal Structure of Photosystem II from Thermosynechococcus elongatus | 分子名称: | (1S)-2-(ALPHA-L-ALLOPYRANOSYLOXY)-1-[(TRIDECANOYLOXY)METHYL]ETHYL PALMITATE, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | 著者 | Loll, B, Kern, J, Saenger, W, Zouni, A, Biesiadka, J. | 登録日 | 2005-09-06 | 公開日 | 2005-12-27 | 最終更新日 | 2017-12-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Towards complete cofactor arrangement in the 3.0 A resolution structure of photosystem II NATURE, 438, 2005
|
|
2L63
| |
2ZXW
| Bovine heart cytochrome c oxidase at the fully oxidized state (1-s X-ray exposure dataset) | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | 著者 | Aoyama, H, Muramoto, K, Shinzawa-Itoh, K, Hirata, K, Yamashita, E, Tsukihara, T, Ogura, T, Yoshikawa, S. | 登録日 | 2009-01-08 | 公開日 | 2009-02-24 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A peroxide bridge between Fe and Cu ions in the O2 reduction site of fully oxidized cytochrome c oxidase could suppress the proton pump Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
2JFA
| ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH AN AFFINITY-SELECTED COREPRESSOR PEPTIDE | 分子名称: | COREPRESSOR PEPTIDE, ESTROGEN RECEPTOR, RALOXIFENE, ... | 著者 | Heldring, N, Pawson, T, McDonnell, D, Treuter, E, Gustafsson, J.A, Pike, A.C.W. | 登録日 | 2007-01-29 | 公開日 | 2007-02-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structural Insights Into Corepressor Recognition by Antagonist-Bound Estrogen Receptors. J.Biol.Chem., 282, 2007
|
|
3CSI
| |
3CHP
| Crystal structure of leukotriene a4 hydrolase in complex with (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid | 分子名称: | (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid, ACETATE ION, IMIDAZOLE, ... | 著者 | Thunnissen, M.M.G.M, Adler, M, Whitlow, M. | 登録日 | 2008-03-10 | 公開日 | 2008-04-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg.Med.Chem., 16, 2008
|
|
3CS8
| |
3CSH
| |
2JP5
| |
3CU8
| Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome | 分子名称: | 14-3-3 protein zeta/delta, MAGNESIUM ION, PROPANOIC ACID, ... | 著者 | Schumacher, B, Weyand, M, Kuhlmann, J, Ottmann, C. | 登録日 | 2008-04-16 | 公開日 | 2009-05-05 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol. Cell. Biol., 30, 2010
|
|
2AL4
| CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH quisqualate and CX614. | 分子名称: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE, Glutamate receptor 2, ... | 著者 | Jin, R, Clark, S, Weeks, A.M, Dudman, J.T, Gouaux, E, Partin, K.M. | 登録日 | 2005-08-04 | 公開日 | 2005-10-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Mechanism of positive allosteric modulators acting on AMPA receptors. J.Neurosci., 25, 2005
|
|
3D29
| Proteasome Inhibition by Fellutamide B | 分子名称: | (3R)-3-HYDROXYDODECANOIC ACID, Fellutamide B, PRE10 isoform 1, ... | 著者 | Groll, M, Hines, J, Fahnestock, M, Crews, M.C. | 登録日 | 2008-05-07 | 公開日 | 2008-06-10 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis Chem.Biol., 15, 2008
|
|
3CEK
| Crystal structure of human dual specificity protein kinase (TTK) | 分子名称: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, Dual specificity protein kinase TTK | 著者 | Filippakopoulos, P, Soundararajan, M, Keates, T, Elkins, J.M, King, O, Fedorov, O, Picaud, S.S, Pike, A.C.W, Roos, A, Pilka, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2008-02-29 | 公開日 | 2008-03-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol., 6, 2010
|
|
3CSU
| CATALYTIC TRIMER OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE | 分子名称: | CALCIUM ION, PROTEIN (ASPARTATE CARBAMOYLTRANSFERASE) | 著者 | Beernink, P.T, Endrizzi, J.A, Alber, T, Schachman, H.K. | 登録日 | 1999-04-22 | 公開日 | 1999-05-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Assessment of the allosteric mechanism of aspartate transcarbamoylase based on the crystalline structure of the unregulated catalytic subunit. Proc.Natl.Acad.Sci.USA, 96, 1999
|
|
2JF9
| ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH A TAMOXIFEN-SPECIFIC PEPTIDE ANTAGONIST | 分子名称: | 1,2-ETHANEDIOL, 4-HYDROXYTAMOXIFEN, AB5 PEPTIDE, ... | 著者 | Heldring, N, Pawson, T, McDonnell, D, Treuter, E, Gustafsson, J.A, Pike, A.C.W. | 登録日 | 2007-01-29 | 公開日 | 2007-02-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Insights Into Corepressor Recognition by Antagonist-Bound Estrogen Receptors. J.Biol.Chem., 282, 2007
|
|
3D6C
| Crystal structure of Staphylococcal nuclease variant PHS L38E at cryogenic temperature | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | 著者 | Harms, M.J, Schlessman, J.L, Sue, G.R, Garcia-Moreno, E.B. | 登録日 | 2008-05-19 | 公開日 | 2008-11-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The pK(a) values of acidic and basic residues buried at the same internal location in a protein are governed by different factors. J.Mol.Biol., 389, 2009
|
|
2JSH
| obestatin NMR structure in SDS/DPC micellar solution | 分子名称: | Appetite-regulating hormone, Obestatin | 著者 | D'Ursi, A.M, Scrima, M, Esposito, C, Campiglia, P. | 登録日 | 2007-07-05 | 公開日 | 2008-10-21 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Obestatin conformational features: a strategy to unveil obestatin's biological role? Biochem.Biophys.Res.Commun., 363, 2007
|
|
2LK0
| |
2LHA
| Solution structure of C2B with IP6 | 分子名称: | INOSITOL HEXAKISPHOSPHATE, Synaptotagmin-1 | 著者 | Joung, M, Mohan, S.K, Yu, C. | 登録日 | 2011-08-08 | 公開日 | 2012-05-02 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Molecular Level Interaction of Inositol Hexaphosphate with the C2B Domain of Human Synaptotagmin I Biochemistry, 2012
|
|
5A3U
| HIF prolyl hydroxylase 2 (PHD2/EGLN1) in complex with 6-(5-oxo-4-(1H- 1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinic acid | 分子名称: | 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinic acid, EGL NINE HOMOLOG 1, MANGANESE (II) ION | 著者 | Chowdhury, R, Gomez-Perez, V, Schofield, C.J. | 登録日 | 2015-06-03 | 公開日 | 2015-06-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. Plos One, 10, 2015
|
|
4WX7
| Crystal structure of adenovirus 8 protease with a nitrile inhibitor | 分子名称: | 3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-N-(2-{[(2Z)-2-iminoethyl]amino}-2-oxoethyl)-4-methoxybenzamide, PVI, Protease | 著者 | Grosche, P, Sirockin, F, Mac Sweeney, A, Ramage, P, Erbel, P, Melkko, S, Bernardi, A, Hughes, N, Ellis, D, Combrink, K, Jarousse, N, Altmann, E. | 登録日 | 2014-11-13 | 公開日 | 2015-01-14 | 最終更新日 | 2015-01-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure-based design and optimization of potent inhibitors of the adenoviral protease. Bioorg.Med.Chem.Lett., 25, 2015
|
|
2LZG
| NMR Structure of Mdm2 (6-125) with Pip-1 | 分子名称: | E3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid | 著者 | Michelsen, K.B, Jordan, J.B, Lewis, J, Long, A.M, Yang, E, Rew, Y, Zhou, J, Yakowec, P, Schnier, P.D, Huang, X, Poppe, L. | 登録日 | 2012-10-02 | 公開日 | 2012-11-07 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors. J.Am.Chem.Soc., 134, 2012
|
|
4WYI
| |
5AGR
| Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct (S)-3-(Aminomethyl)-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP | 分子名称: | 1,2-ETHANEDIOL, 3-AMINOMETHYL-7-(ETHOXY)-3H-BENZO[C][1,2]OXABOROL-1-OL modified adenosine, LEUCINE, ... | 著者 | Palencia, A, Li, X, Alley, M.R.K, Ding, C, Easom, E.E, Hernandez, V, Meewan, M, Mohan, M, Rock, F.L, Franzblau, S.G, Wang, Y, Lenaerts, A.J, Parish, T, Cooper, C.B, Waters, M.G, Ma, Z, Mendoza, A, Barros, D, Cusack, S, Plattner, J.J. | 登録日 | 2015-02-03 | 公開日 | 2016-03-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60, 2016
|
|