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4WX7

Crystal structure of adenovirus 8 protease with a nitrile inhibitor

Summary for 4WX7
Entry DOI10.2210/pdb4wx7/pdb
DescriptorProtease, PVI, 3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-N-(2-{[(2Z)-2-iminoethyl]amino}-2-oxoethyl)-4-methoxybenzamide, ... (4 entities in total)
Functional Keywordscysteine protease, inhibitor, covalent, hydrolase
Biological sourceHuman adenovirus D serotype 8 (HAdV-8)
More
Total number of polymer chains4
Total formula weight49656.69
Authors
Grosche, P.,Sirockin, F.,Mac Sweeney, A.,Ramage, P.,Erbel, P.,Melkko, S.,Bernardi, A.,Hughes, N.,Ellis, D.,Combrink, K.,Jarousse, N.,Altmann, E. (deposition date: 2014-11-13, release date: 2015-01-14, Last modification date: 2015-01-28)
Primary citationGrosche, P.,Sirockin, F.,Mac Sweeney, A.,Ramage, P.,Erbel, P.,Melkko, S.,Bernardi, A.,Hughes, N.,Ellis, D.,Combrink, K.D.,Jarousse, N.,Altmann, E.
Structure-based design and optimization of potent inhibitors of the adenoviral protease.
Bioorg.Med.Chem.Lett., 25:438-443, 2015
Cited by
PubMed: 25571794
DOI: 10.1016/j.bmcl.2014.12.057
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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